Precision Health Clinical Trials
GRETeL: Tumor Response to Standard Radiotherapy and TMZ Patients With GBM
Conditions: Glioblastoma; Glioma, Malignant
Intervention:
Sponsors: Duke University; Personalis Inc.
Recruiting
Intervention:
Sponsors: Duke University; Personalis Inc.
Recruiting
For more information, visit the Study URL.
Hypoxia-driven Prostate Cancer Genomics (HYPROGEN)
Conditions: Prostate Cancer; Hypoxia
Interventions: Drug: Optional non-IMP pimonidazole; Diagnostic Test: CT-guided Bone Biopsy; Diagnostic Test: TRUS-guided Targeted Transperineal Prostate Biopsy; Procedure: Radical Prostatectomy; Diagnostic Test: Whole-body MRI; Diagnostic Test: Prostate MRI scans; Other: Baseline bloods - for germline testing; Other: Baseline bloods for CTCs and ct DNA taken at same time as baseline bloods in Arm 1; Other: Post-pimonidazole bloods for CTCs and ctDNA
Sponsors: The Christie NHS Foundation Trust; Prostate Cancer UK
Recruiting
Interventions: Drug: Optional non-IMP pimonidazole; Diagnostic Test: CT-guided Bone Biopsy; Diagnostic Test: TRUS-guided Targeted Transperineal Prostate Biopsy; Procedure: Radical Prostatectomy; Diagnostic Test: Whole-body MRI; Diagnostic Test: Prostate MRI scans; Other: Baseline bloods - for germline testing; Other: Baseline bloods for CTCs and ct DNA taken at same time as baseline bloods in Arm 1; Other: Post-pimonidazole bloods for CTCs and ctDNA
Sponsors: The Christie NHS Foundation Trust; Prostate Cancer UK
Recruiting
For more information, visit the Study URL.
MoleculAr Profiling for Pediatric and Young Adult Cancer Treatment Stratification 2
Conditions: Solid Tumor; Leukemia
Intervention: Biological: Solid tumor and CT DNA
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Recruiting
Intervention: Biological: Solid tumor and CT DNA
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Recruiting
For more information, visit the Study URL.
Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
Conditions: Metastatic Malignant Solid Neoplasm; Unresectable Malignant Solid Neoplasm
Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Diagnostic Imaging; Biological: Novobiocin Sodium
Sponsor: National Cancer Institute (NCI)
Recruiting
Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Diagnostic Imaging; Biological: Novobiocin Sodium
Sponsor: National Cancer Institute (NCI)
Recruiting
For more information, visit the Study URL.
Baby Detect : Genomic Newborn Screening
Conditions: Congenital Adrenal Hyperplasia; Familial Hyperinsulinemic Hypoglycemia 1; Phosphoglucomutase 1 Deficiency; Maturity Onset Diabetes of the Young; Cystic Fibrosis; Hypophosphatasia, Infantile; Congenital Hypothyroidism; DAVID; Pituitary Hormone Deficiency, Combined; Diamond Blackfan Anemia; Wiskott-Aldrich Syndrome; Fanconi Anemia; Hemophilia A; Hemophilia B; Glucose 6 Phosphate Dehydrogenase Deficiency; Alpha-Thalassemia; Sickle Cell Disease; Shwachman-Diamond Syndrome; Alpha 1-Antitrypsin Deficiency; Inflammatory Bowel Disease 25, Autosomal Recessive; Wilson Disease; Progressive Familial Intrahepatic Cholestasis; Crigler-Najjar Syndrome; DIAR4; Familial Chylomicronemia; Lysosomal Acid Lipase Deficiency; Familial Hemophagocytic Lymphocytosis; Griscelli Syndrome; Chediak-Higashi Syndrome; Severe Congenital Neutropenia; SCID; Chronic Granulomatous Disease; Menkes Disease; X-ALD; Smith-Lemli-Opitz Syndrome; Ataxia With Vitamin E Deficiency; THMD5; THMD4; Thiamine-Responsive Megaloblastic Anemia; Thiamine Metabolism Dysfunction Syndrome 2; GOT2 DEFICIENCY; Cerebral Folate Transport Deficiency; Segawa Syndrome, Autosomal Recessive; Congenital Myasthenic Syndrome; Metachromatic Leukodystrophy; Sepiapterin Reductase Deficiency; Dopamine Beta Hydroxylase Deficiency; Glut1 Deficiency Syndrome; Late-Infantile Neuronal Ceroid Lipofuscinosis; Aromatic L-amino Acid Decarboxylase Deficiency; Charcot-Marie-Tooth Disease, Type 6C; Hereditary Hyperekplexia; Brain Dopamine-Serotonin Vesicular Transport Disease; Very Long Chain Hydroxy Acyl Dehydrogenase Deficiency; Tyrosinemia, Type I; Disaccharide Intolerance I; Beta Ketothiolase Deficiency; Phosphoglycerate Dehydrogenase Deficiency; Succinyl-Coa 3-Oxoacid Transferase Deficiency; Pyridoxine-5'-Phosphate Oxidase Deficiency; Pyridoxine-Dependent Epilepsy; Propionic Acidemia; Pompe Disease; Phenylalanine Hydroxylase Deficiency; Ornithine Transcarbamylase Deficiency; N Acetyl Glutamate Synthethase Deficiency; Riboflavin Deficiency; Maple Syrup Urine Disease; Medium Chain Acyl CoA Dehydrogenase Deficiency; Malonic Acidemia; Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency; Isovaleric Acidemia; Phosphoserine Aminotransferase Deficiency; Phosphoserine Phosphatase Deficiency; Spatccm; Hyperornithinemia-Hyperammonemia-Homocitrullinuria; MRT8, FORMERLY; S-Adenosylhomocysteine Hydrolase Deficiency; Mucopolysaccharidosis VII; Mucopolysaccharidosis VI; Mucopolysaccharidosis IV A; Mucopolysaccharidosis II; Mucopolysaccharidosis I; Transcobalamin Deficiency; Isolated Methylmalonic Acidemia; Cobalamin Deficiency; Homocystinuria; Holocarboxylase Synthetase Deficiency; Fanconi Bickel Syndrome; Glycogen Storage Disease; Glycine Encephalopathy; Glutaric Acidemia I; Glucose Galactose Malabsorption; Gaucher Disease, Type 1; Galactosemias; Fructosemia; Fructose-1,6-Diphosphatase Deficiency; Carbamoyl Phosphate Synthase 1 Deficiency; Citrullinemia Type II; Citrullinemia 1; Creatine Deficiency Syndrome; Systemic Primary Carnitine Deficiency; Carnitine Palmitoyltransferase Deficiency 2; Carnitine Palmitoyltransferase Deficiency 1; Carnitine Acylcarnitine Translocase Deficiency; Riboflavin Transporter Deficiency; Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency; Andersen Tawil Syndrome; Timothy Syndrome; Jervell-Lange Nielsen Syndrome; Catecholaminergic Polymorphic Ventricular Tachycardia; Familial Hypertrophic Cardiomyopathy Type 4; Pseudohypoaldosteronism, Type II; Pseudohypoaldosteronism Type 1; Primary Hyperoxaluria; X Linked Hypophosphatemia; Hereditary Nephrogenic Diabetes Insipidus; Cystinosis; Congenital Nephrotic Syndrome, Finnish Type; Alport Syndrome; Hereditary Retinoblastoma; Biotinidase Deficiency; Aciduria, Argininosuccinic; Arginemia; ACAD9 Deficiency; 3-Hydroxy 3-Methyl Glutaric Aciduria; 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency
Intervention:
Sponsors: Laurent Servais; Centre Hospitalier Universitaire de Liege; University of Liege
Recruiting
Intervention:
Sponsors: Laurent Servais; Centre Hospitalier Universitaire de Liege; University of Liege
Recruiting
For more information, visit the Study URL.
Testing How the Body Responds to the Drug CBX-12 in Patients With Advanced Solid Cancers
Conditions: Advanced Malignant Solid Neoplasm; Metastatic Malignant Solid Neoplasm
Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: pH Low Insertion Peptide-exatecan Conjugate CBX-12
Sponsor: National Cancer Institute (NCI)
Not yet recruiting
Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: pH Low Insertion Peptide-exatecan Conjugate CBX-12
Sponsor: National Cancer Institute (NCI)
Not yet recruiting
For more information, visit the Study URL.
Single-cell RNA Sequencing Resolves the Regulatory Role of HBV on the Hepatocellular Carcinoma Immune Microenvironment
Conditions: HBV; Primary Liver Cancer
Intervention: Diagnostic Test: HBV DNA Sequencing
Sponsor: Fubing Wang
Recruiting
Intervention: Diagnostic Test: HBV DNA Sequencing
Sponsor: Fubing Wang
Recruiting
For more information, visit the Study URL.
Pharmacogenomics on Individualized Precise Treatment of Patients With Depression
Conditions: Pharmacogenomics; Depression
Intervention: Diagnostic Test: Genomic analysis of antidepressants
Sponsor: Tongji University
Not yet recruiting
Intervention: Diagnostic Test: Genomic analysis of antidepressants
Sponsor: Tongji University
Not yet recruiting
For more information, visit the Study URL.
Gastric Cancer Early Detection by Multi-dimensional Analysis of cfDNA
Condition: Gastric Cancer
Intervention: Genetic: whole genomic methylation and fragmentation profile analysis of cfDNA
Sponsors: GeneCast Biotechnology Co., Ltd.; The First Affiliated Hospital of Air Force Military Medical University (Xijing Hospital)
Recruiting
Intervention: Genetic: whole genomic methylation and fragmentation profile analysis of cfDNA
Sponsors: GeneCast Biotechnology Co., Ltd.; The First Affiliated Hospital of Air Force Military Medical University (Xijing Hospital)
Recruiting
For more information, visit the Study URL.
Biomarker Analysis of HIPEC Combined With PD1/PDL1 Inhibitor for Gastric Cancer With Peritoneal Metastasis
Condition: Gastric Cancer
Intervention: Other: Observational
Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Not yet recruiting
Intervention: Other: Observational
Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Not yet recruiting
For more information, visit the Study URL.