Precision Health Clinical Trials

GRETeL: Tumor Response to Standard Radiotherapy and TMZ Patients With GBM

Conditions:   Glioblastoma;   Glioma, Malignant
Intervention:  
Sponsors:   Duke University;   Personalis Inc.
Recruiting

Hypoxia-driven Prostate Cancer Genomics (HYPROGEN)

Conditions:   Prostate Cancer;   Hypoxia
Interventions:   Drug: Optional non-IMP pimonidazole;   Diagnostic Test: CT-guided Bone Biopsy;   Diagnostic Test: TRUS-guided Targeted Transperineal Prostate Biopsy;   Procedure: Radical Prostatectomy;   Diagnostic Test: Whole-body MRI;   Diagnostic Test: Prostate MRI scans;   Other: Baseline bloods - for germline testing;   Other: Baseline bloods for CTCs and ct DNA taken at same time as baseline bloods in Arm 1;   Other: Post-pimonidazole bloods for CTCs and ctDNA
Sponsors:   The Christie NHS Foundation Trust;   Prostate Cancer UK
Recruiting

Testing How the Body Responds to the Drug CBX-12 in Patients With Advanced Solid Cancers

Conditions:   Advanced Malignant Solid Neoplasm;   Metastatic Malignant Solid Neoplasm
Interventions:   Procedure: Biopsy;   Procedure: Biospecimen Collection;   Procedure: Computed Tomography;   Drug: pH Low Insertion Peptide-exatecan Conjugate CBX-12
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

Baby Detect : Genomic Newborn Screening

Conditions:   Congenital Adrenal Hyperplasia;   Familial Hyperinsulinemic Hypoglycemia 1;   Phosphoglucomutase 1 Deficiency;   Maturity Onset Diabetes of the Young;   Cystic Fibrosis;   Hypophosphatasia, Infantile;   Congenital Hypothyroidism;   DAVID;   Pituitary Hormone Deficiency, Combined;   Diamond Blackfan Anemia;   Wiskott-Aldrich Syndrome;   Fanconi Anemia;   Hemophilia A;   Hemophilia B;   Glucose 6 Phosphate Dehydrogenase Deficiency;   Alpha-Thalassemia;   Sickle Cell Disease;   Shwachman-Diamond Syndrome;   Alpha 1-Antitrypsin Deficiency;   Inflammatory Bowel Disease 25, Autosomal Recessive;   Wilson Disease;   Progressive Familial Intrahepatic Cholestasis;   Crigler-Najjar Syndrome;   DIAR4;   Familial Chylomicronemia;   Lysosomal Acid Lipase Deficiency;   Familial Hemophagocytic Lymphocytosis;   Griscelli Syndrome;   Chediak-Higashi Syndrome;   Severe Congenital Neutropenia;   SCID;   Chronic Granulomatous Disease;   Menkes Disease;   X-ALD;   Smith-Lemli-Opitz Syndrome;   Ataxia With Vitamin E Deficiency;   THMD5;   THMD4;   Thiamine-Responsive Megaloblastic Anemia;   Thiamine Metabolism Dysfunction Syndrome 2;   GOT2 DEFICIENCY;   Cerebral Folate Transport Deficiency;   Segawa Syndrome, Autosomal Recessive;   Congenital Myasthenic Syndrome;   Metachromatic Leukodystrophy;   Sepiapterin Reductase Deficiency;   Dopamine Beta Hydroxylase Deficiency;   Glut1 Deficiency Syndrome;   Late-Infantile Neuronal Ceroid Lipofuscinosis;   Aromatic L-amino Acid Decarboxylase Deficiency;   Charcot-Marie-Tooth Disease, Type 6C;   Hereditary Hyperekplexia;   Brain Dopamine-Serotonin Vesicular Transport Disease;   Very Long Chain Hydroxy Acyl Dehydrogenase Deficiency;   Tyrosinemia, Type I;   Disaccharide Intolerance I;   Beta Ketothiolase Deficiency;   Phosphoglycerate Dehydrogenase Deficiency;   Succinyl-Coa 3-Oxoacid Transferase Deficiency;   Pyridoxine-5'-Phosphate Oxidase Deficiency;   Pyridoxine-Dependent Epilepsy;   Propionic Acidemia;   Pompe Disease;   Phenylalanine Hydroxylase Deficiency;   Ornithine Transcarbamylase Deficiency;   N Acetyl Glutamate Synthethase Deficiency;   Riboflavin Deficiency;   Maple Syrup Urine Disease;   Medium Chain Acyl CoA Dehydrogenase Deficiency;   Malonic Acidemia;   Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency;   Isovaleric Acidemia;   Phosphoserine Aminotransferase Deficiency;   Phosphoserine Phosphatase Deficiency;   Spatccm;   Hyperornithinemia-Hyperammonemia-Homocitrullinuria;   MRT8, FORMERLY;   S-Adenosylhomocysteine Hydrolase Deficiency;   Mucopolysaccharidosis VII;   Mucopolysaccharidosis VI;   Mucopolysaccharidosis IV A;   Mucopolysaccharidosis II;   Mucopolysaccharidosis I;   Transcobalamin Deficiency;   Isolated Methylmalonic Acidemia;   Cobalamin Deficiency;   Homocystinuria;   Holocarboxylase Synthetase Deficiency;   Fanconi Bickel Syndrome;   Glycogen Storage Disease;   Glycine Encephalopathy;   Glutaric Acidemia I;   Glucose Galactose Malabsorption;   Gaucher Disease, Type 1;   Galactosemias;   Fructosemia;   Fructose-1,6-Diphosphatase Deficiency;   Carbamoyl Phosphate Synthase 1 Deficiency;   Citrullinemia Type II;   Citrullinemia 1;   Creatine Deficiency Syndrome;   Systemic Primary Carnitine Deficiency;   Carnitine Palmitoyltransferase Deficiency 2;   Carnitine Palmitoyltransferase Deficiency 1;   Carnitine Acylcarnitine Translocase Deficiency;   Riboflavin Transporter Deficiency;   Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency;   Andersen Tawil Syndrome;   Timothy Syndrome;   Jervell-Lange Nielsen Syndrome;   Catecholaminergic Polymorphic Ventricular Tachycardia;   Familial Hypertrophic Cardiomyopathy Type 4;   Pseudohypoaldosteronism, Type II;   Pseudohypoaldosteronism Type 1;   Primary Hyperoxaluria;   X Linked Hypophosphatemia;   Hereditary Nephrogenic Diabetes Insipidus;   Cystinosis;   Congenital Nephrotic Syndrome, Finnish Type;   Alport Syndrome;   Hereditary Retinoblastoma;   Biotinidase Deficiency;   Aciduria, Argininosuccinic;   Arginemia;   ACAD9 Deficiency;   3-Hydroxy 3-Methyl Glutaric Aciduria;   3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency
Intervention:  
Sponsors:   Laurent Servais;   Centre Hospitalier Universitaire de Liege;   University of Liege
Recruiting

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

Conditions:   Metastatic Malignant Solid Neoplasm;   Unresectable Malignant Solid Neoplasm
Interventions:   Procedure: Biopsy;   Procedure: Biospecimen Collection;   Procedure: Diagnostic Imaging;   Biological: Novobiocin Sodium
Sponsor:   National Cancer Institute (NCI)
Recruiting

MoleculAr Profiling for Pediatric and Young Adult Cancer Treatment Stratification 2

Conditions:   Solid Tumor;   Leukemia
Intervention:   Biological: Solid tumor and CT DNA
Sponsor:   Gustave Roussy, Cancer Campus, Grand Paris
Recruiting

Single-cell RNA Sequencing Resolves the Regulatory Role of HBV on the Hepatocellular Carcinoma Immune Microenvironment

Conditions:   HBV;   Primary Liver Cancer
Intervention:   Diagnostic Test: HBV DNA Sequencing
Sponsor:   Fubing Wang
Recruiting

Pharmacogenomics on Individualized Precise Treatment of Patients With Depression

Conditions:   Pharmacogenomics;   Depression
Intervention:   Diagnostic Test: Genomic analysis of antidepressants
Sponsor:   Tongji University
Not yet recruiting

Gastric Cancer Early Detection by Multi-dimensional Analysis of cfDNA

Condition:   Gastric Cancer
Intervention:   Genetic: whole genomic methylation and fragmentation profile analysis of cfDNA
Sponsors:   GeneCast Biotechnology Co., Ltd.;   The First Affiliated Hospital of Air Force Military Medical University (Xijing Hospital)
Recruiting

Biomarker Analysis of HIPEC Combined With PD1/PDL1 Inhibitor for Gastric Cancer With Peritoneal Metastasis

Condition:   Gastric Cancer
Intervention:   Other: Observational
Sponsor:   Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Not yet recruiting

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