Precision Health Clinical Trials

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Conditions:   Gastrointestinal Cancer;   Head and Neck Cancer;   Dihydropyrimidine Dehydrogenase Deficiency;   UGT1A1 Gene Mutation;   Breast Cancer
Intervention:   Other: Availability of clinical decision support based on pharmacogenomic results.
Sponsor:   University of Chicago

Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)

Conditions:   Lung Cancer, Non-small Cell;   EGFR Gene Mutation;   EGFR-TKI Resistant Mutation;   Primary Resistance;   Circulating Tumor DNA
Interventions:   Other: Genomic profiles detection;   Other: circulating tumor DNA detection
Sponsors:   Second Xiangya Hospital of Central South University;   Xiangya Hospital of Central South University;   Shanghai Chest Hospital;   West China Hospital;   Hunan Cancer Hospital;   The Third Xiangya Hospital of Central South University;   The First Affiliated Hospital of Xiamen University;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   China-Japan Friendship Hospital;   Fudan University;   First Affiliated Hospital of Kunming Medical University;   Loudi Central Hospital;   ZhuZhou Central Hospital;   Xiangtan Central Hospital;   First People's Hospital of Chenzhou;   Yueyang Central Hospital;   Yongzhou Central Hospital;   The First Affiliated Hospital of University of South China;   Hunan Provincial People's Hospital;   Shaoyang Central Hospital;   Yiyang Central Hospital;   Changsha Central Hospital;   The first people's hospital of Guiyang;   Wuhan Union Hospital, China;   Renmin Hospital of Wuhan University;   The First People's Hospital of Changde;   Zhuzhou Second Hospital;   First Hospital of Changsha;   Hengyang Central Hospital;   Huaihua first people's Hospital;   The First People's Hospital of Xiangtan;   University of South China Affiliated Nanhua Hospital;   Xiangxi Autonomous Prefecture People's Hospital;   People's Hospital of Zhangjiajie;   Second People's Hospital Of Huaihua;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   The Third Hospital of Changsha;   Xiangya Changde Hospital;   Changsha County first People's Hospital;   Hunan Provincial Straight Hospital of Traditional Chinese Medicine;   Liuyang Hospital of traditional Chinese Medicine;   Second People's Hospital of Hunan;   First Affiliated Hospital of Guangxi Medical University;   Guiyang Public Health Treatment Center;   The Affiliated Bethune Hospital of Shanxi Medical University;   The First Affiliated Hospital of Hunan University of Chinese Medicine;   Tongji Hospital;   The First Affiliated Hospital of Nanchang University

Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C

Condition:   Niemann-Pick Disease, Type C
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Molecular Characterization of Blastocystis Isolates From Human by Restriction Fragment Length Polymorphism (RFLP) Analysis

Condition:   Blastocystis Infections
Intervention:   Diagnostic Test: RFLP analysis of SSU rRNA
Sponsor:   Sohag University
Not yet recruiting

Molecular Epidemiology of Pediatric Germ Cell Tumors

Conditions:   Germ Cell Tumor;   Germinoma;   Teratoma;   Embryonal Carcinoma;   Yolk Sac Tumor;   Choriocarcinoma;   Mixed Germ Cell Tumor;   Late Effects;   Pediatric Germ Cell Tumor
Interventions:   Other: Questionnaire Administration;   Other: Tumor Specimen Collection;   Other: Germline DNA Samples;   Procedure: Blood Sample Collection
Sponsor:   Children's Oncology Group

A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)

Condition:   Colorectal Cancer
Sponsor:   Memorial Sloan Kettering Cancer Center

The Energy Cost of Living in the Developing World

Condition:   Food Requirements
Intervention:   Other: No intervention
Sponsors:   Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences;   Université Cheikh Anta Diop de Dakar;   Moi University;   Tehran University of Medical Sciences;   Imperial College London Diabetes Centre
Not yet recruiting

Precision Medicine for Liver Tumours With Quantitative Magnetic Resonance Imaging and Whole Genome Sequencing

Conditions:   Liver Cancer;   Liver Metastasis Colon Cancer
Intervention:   Genetic: utility of whole genome sequencing (WGS) to aid clinical decision making in patients referred for liver resection
Sponsor:   Perspectum

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Azacitidine;   Procedure: Biospecimen Collection;   Procedure: Bone Marrow Aspirate;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Venetoclax
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan

Condition:   Oropharyngeal Squamous Cell Carcinoma
Sponsors:   National Health Research Institutes, Taiwan;   National Taiwan University Hospital;   Taipei Veterans General Hospital, Taiwan;   China Medical University Hospital;   Taichung Veterans General Hospital;   National Cheng-Kung University Hospital;   Kaohsiung Veterans General Hospital.