Precision Health Clinical Trials

Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.

Conditions:   Romano-Ward Syndrome;   Long QT Syndrome;   Compulsive Behavior;   Healthy Individuals
Interventions:   Behavioral: Cognitive assessment of obsessive-compulsive and impulsive behaviours;   Genetic: Genomic analysis;   Diagnostic Test: Glucoregulation assessment
Sponsors:   Biotrial;   European Union;   Nantes University Hospital

A Multi-Center Natural History Study of Precision-Based Genomics in Prostate Cancer

Condition:   Prostate Cancer
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

Non-invasive Preimplantation Genetic Testing for Aneuploidies Using Cell-free DNA in Spent Culture Media

Condition:   Secondary Infertility
Intervention:   Diagnostic Test: PGT-A / niPGT-A
Sponsor:   ART Fertility Clinics LLC
Not yet recruiting

Trifecta-Heart cfDNA-MMDx Study

Condition:   Heart Transplant Rejection
Interventions:   Diagnostic Test: MMDx diagnostic test;   Diagnostic Test: Prospera;   Diagnostic Test: HLA antibody
Sponsors:   University of Alberta;   Natera, Inc.;   One Lambda

Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve

Condition:   Diminished Ovarian Reserve
Intervention:   Other: whole-genome sequencing
Sponsors:   Nanfang Hospital of Southern Medical University;   Ferring Pharmaceuticals

LIQUIK: LIQUId Biopsy for Detection of Actionable Genomic BiomarKers in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)

Condition:   Non Small Cell Lung Cancer
Sponsor:   Lucence Health Inc.

A Trial for Relapsed and Relapsed/Refractory Multiple Myeloma Patients

Conditions:   Multiple Myeloma;   Deletion 17P Syndrome
Interventions:   Drug: Daratumumab;   Drug: Pomalidomide;   Drug: Dexamethasone
Sponsor:   Fondazione EMN Italy Onlus

Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

Condition:   NSCLC
Intervention:   Diagnostic Test: ctDNA, tumor NGS
Sponsors:   Lung Cancer Mutation Consortium;   Lung Cancer Research Foundation
Not yet recruiting

Research of Pathological Imaging Diagnosis of Ocular Tumors Based on New Artificial Intelligence Algorithm

Conditions:   Melanoma (Skin);   Melanoma in Situ;   Nevus Eye;   Sebaceous Gland Carcinoma of the Eyelid;   Basal Cell Carcinoma;   Squamous Cell Carcinoma in Situ;   Ocular Tumor
Sponsor:   Peking University
Not yet recruiting

A Pharmacodynamics-Driven Trial of Talazoparib, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage Response

Condition:   Solid Tumors
Intervention:   Drug: talazoparib
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting