Precision Health Clinical Trials

Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension

Conditions:   Hypertensive Disorder of Pregnancy;   Vitamin D Deficiency
Intervention:   Diagnostic Test: Blood taking
Sponsors:   Universiti Putra Malaysia;   Ministry of Higher Education Malaysia

Liquid Biopsy in Advanced Oligometastatic NSCLC Receiving Surgery

Conditions:   Non-small Cell Lung Cancer;   Oligometastatic Disease
Intervention:   Genetic: ctDNA testing and whole exome sequencing
Sponsor:   Guangdong Provincial People's Hospital

Molecular Profiling and Dynamic Changes of ctDNA in Unresectable Locally Advanced NSCLC

Conditions:   Lung Cancer;   Stage III Lung Cancer;   Unresectable Lung Carcinoma
Interventions:   Procedure: Sample collection;   Diagnostic Test: Characterization of the tumoral tissue genomic alterations;   Drug: Chemoradiation treatment regimen and maintenance (if amenable);   Diagnostic Test: Genomic and methylation analysis in liquid biopsy
Sponsors:   Parc de Salut Mar;   Guardant Health, Inc.

Chinese Regional Spinal Muscular Atrophy Patient Registration Study

Condition:   Recruitment
Sponsor:   The Children's Hospital of Zhejiang University School of Medicine

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Conditions:   Locally Advanced Leiomyosarcoma;   Metastatic Leiomyosarcoma;   Stage III Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IV Uterine Corpus Leiomyosarcoma AJCC v8;   Unresectable Leiomyosarcoma;   Uterine Corpus Leiomyosarcoma
Interventions:   Drug: Olaparib;   Drug: Temozolomide;   Drug: Trabectedin;   Drug: Pazopanib
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)

Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM

Condition:   Monkeypox
Intervention:   Biological: Samples
Sponsor:   University Hospital, Toulouse
Not yet recruiting

ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer

Conditions:   Rectal Cancer;   Non Metastatic Rectal Cancer
Intervention:   Other: ctDNA
Sponsors:   Massachusetts General Hospital;   C2i Genomics;   Spier Family Foundation
Not yet recruiting

Refinement and Validation of a Diagnostic Model (GAMAD) for Early Detection of Hepatocellular Carcinoma

Condition:   Hepatocellular Carcinoma
Intervention:   Diagnostic Test: GAMAD
Sponsors:   Singlera Genomics Inc.;   The First Hospital of Jilin University

Screening for Cystic Fibrosis and Cystic Fibrosis Related Disorders in Chinese Adults With Bronchiectasis

Condition:   Cystic Fibrosis, Pulmonary
Intervention:   Diagnostic Test: Sweat Test
Sponsor:   Shanghai Pulmonary Hospital, Shanghai, China

A Biomarker Study for Predicting the Efficacy of Neoadjuvant Sintilimab Plus SOX for Gastric Adenocarcinoma.

Condition:   Gastric Cancer
Intervention:   Drug: Sintilimab
Sponsors:   The First Affiliated Hospital with Nanjing Medical University;   Innovent Biologics (Suzhou) Co. Ltd.;   Nanjing Geneseeq Technology Inc.
Not yet recruiting