Precision Health Clinical Trials

Chinese Regional Spinal Muscular Atrophy Patient Registration Study

Condition:   Recruitment
Intervention:  
Sponsor:   The Children's Hospital of Zhejiang University School of Medicine
Recruiting

For more information, visit the Study URL.

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Conditions:   Locally Advanced Leiomyosarcoma;   Metastatic Leiomyosarcoma;   Stage III Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IV Uterine Corpus Leiomyosarcoma AJCC v8;   Unresectable Leiomyosarcoma;   Uterine Corpus Leiomyosarcoma
Interventions:   Drug: Olaparib;   Drug: Temozolomide;   Drug: Trabectedin;   Drug: Pazopanib
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Not yet recruiting

For more information, visit the Study URL.

Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM

Condition:   Monkeypox
Intervention:   Biological: Samples
Sponsor:   University Hospital, Toulouse
Not yet recruiting

For more information, visit the Study URL.

ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer

Conditions:   Rectal Cancer;   Non Metastatic Rectal Cancer
Intervention:   Other: ctDNA
Sponsors:   Massachusetts General Hospital;   C2i Genomics;   Spier Family Foundation
Not yet recruiting

For more information, visit the Study URL.

Establishment of a Clinical Diagnostic Model GAMAD for Early-stage HCC Based on Circulating Tumor DNA Methylation

Condition:   Hepatocellular Carcinoma
Intervention:   Diagnostic Test: GAMAD
Sponsors:   Singlera Genomics Inc.;   The First Hospital of Jilin University
Not yet recruiting

For more information, visit the Study URL.

Screening for Cystic Fibrosis and Cystic Fibrosis Related Disorders in Chinese Adults With Bronchiectasis

Condition:   Cystic Fibrosis, Pulmonary
Intervention:   Diagnostic Test: Sweat Test
Sponsor:   Shanghai Pulmonary Hospital, Shanghai, China
Recruiting

For more information, visit the Study URL.

A Biomarker Study for Predicting the Efficacy of Neoadjuvant Sintilimab Plus SOX for Gastric Adenocarcinoma.

Condition:   Gastric Cancer
Intervention:   Drug: Sintilimab
Sponsors:   The First Affiliated Hospital with Nanjing Medical University;   Innovent Biologics (Suzhou) Co. Ltd.;   Nanjing Geneseeq Technology Inc
Not yet recruiting

For more information, visit the Study URL.

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Conditions:   Gastrointestinal Cancer;   Head and Neck Cancer;   Dihydropyrimidine Dehydrogenase Deficiency;   UGT1A1 Gene Mutation;   Breast Cancer
Intervention:   Other: Availability of clinical decision support based on pharmacogenomic results.
Sponsor:   University of Chicago
Recruiting

For more information, visit the Study URL.

Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)

Conditions:   Lung Cancer, Non-small Cell;   EGFR Gene Mutation;   EGFR-TKI Resistant Mutation;   Primary Resistance;   Circulating Tumor DNA
Interventions:   Other: Genomic profiles detection;   Other: circulating tumor DNA detection
Sponsors:   Fang Wu;   Xiangya Hospital of Central South University;   Shanghai Chest Hospital;   West China Hospital;   Hunan Cancer Hospital;   The Third Xiangya Hospital of Central South University;   The First Affiliated Hospital of Xiamen University;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   China-Japan Friendship Hospital;   Fudan University;   Jiangxi Provincial Cancer Hospital;   The First Affiliated Hospital of Kunming Medical College;   Loudi Central Hospital;   ZhuZhou Central Hospital;   Xiangtan Central Hospital;   First People's Hospital of Chenzhou;   Yueyang Central Hospital;   Yongzhou Central Hospital;   The First Affiliated Hospital of University of South China;   Hunan Provincial People's Hospital;   Shaoyang Central Hospital;   Yiyang Central Hospital;   Changsha Central Hospital;   The first people's hospital of Guiyang;   Wuhan Union Hospital, China;   Renmin Hospital of Wuhan University;   The First People's Hospital of Changde;   Zhuzhou Second Hospital;   First Hospital of Changsha;   Hengyang Central Hospital;   Huaihua first people's Hospital;   The First People's Hospital of Xiangtan;   University of South China Affiliated Nanhua Hospital;   Xiangxi Autonomous Prefecture People's Hospital;   People's Hospital of Zhangjiajie;   Second People's Hospital Of Huaihua;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   The Third Hospital of Changsha;   Xiangya Changde Hospital;   Changsha County first People's Hospital;   Hunan Provincial Straight Hospital of Traditional Chinese Medicine;   Liuyang Hospital of traditional Chinese Medicine
Recruiting

For more information, visit the Study URL.

Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C

Condition:   Niemann-Pick Disease, Type C
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

For more information, visit the Study URL.

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