Precision Health Clinical Trials

Chinese Regional Spinal Muscular Atrophy Patient Registration Study

Condition:   Recruitment
Sponsor:   The Children's Hospital of Zhejiang University School of Medicine

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Conditions:   Locally Advanced Leiomyosarcoma;   Metastatic Leiomyosarcoma;   Stage III Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IV Uterine Corpus Leiomyosarcoma AJCC v8;   Unresectable Leiomyosarcoma;   Uterine Corpus Leiomyosarcoma
Interventions:   Drug: Olaparib;   Drug: Temozolomide;   Drug: Trabectedin;   Drug: Pazopanib
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Not yet recruiting

Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM

Condition:   Monkeypox
Intervention:   Biological: Samples
Sponsor:   University Hospital, Toulouse
Not yet recruiting

ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer

Conditions:   Rectal Cancer;   Non Metastatic Rectal Cancer
Intervention:   Other: ctDNA
Sponsors:   Massachusetts General Hospital;   C2i Genomics;   Spier Family Foundation
Not yet recruiting

Establishment of a Clinical Diagnostic Model GAMAD for Early-stage HCC Based on Circulating Tumor DNA Methylation

Condition:   Hepatocellular Carcinoma
Intervention:   Diagnostic Test: GAMAD
Sponsors:   Singlera Genomics Inc.;   The First Hospital of Jilin University
Not yet recruiting

Screening for Cystic Fibrosis and Cystic Fibrosis Related Disorders in Chinese Adults With Bronchiectasis

Condition:   Cystic Fibrosis, Pulmonary
Intervention:   Diagnostic Test: Sweat Test
Sponsor:   Shanghai Pulmonary Hospital, Shanghai, China

A Biomarker Study for Predicting the Efficacy of Neoadjuvant Sintilimab Plus SOX for Gastric Adenocarcinoma.

Condition:   Gastric Cancer
Intervention:   Drug: Sintilimab
Sponsors:   The First Affiliated Hospital with Nanjing Medical University;   Innovent Biologics (Suzhou) Co. Ltd.;   Nanjing Geneseeq Technology Inc
Not yet recruiting

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Conditions:   Gastrointestinal Cancer;   Head and Neck Cancer;   Dihydropyrimidine Dehydrogenase Deficiency;   UGT1A1 Gene Mutation;   Breast Cancer
Intervention:   Other: Availability of clinical decision support based on pharmacogenomic results.
Sponsor:   University of Chicago

Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)

Conditions:   Lung Cancer, Non-small Cell;   EGFR Gene Mutation;   EGFR-TKI Resistant Mutation;   Primary Resistance;   Circulating Tumor DNA
Interventions:   Other: Genomic profiles detection;   Other: circulating tumor DNA detection
Sponsors:   Fang Wu;   Xiangya Hospital of Central South University;   Shanghai Chest Hospital;   West China Hospital;   Hunan Cancer Hospital;   The Third Xiangya Hospital of Central South University;   The First Affiliated Hospital of Xiamen University;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   China-Japan Friendship Hospital;   Fudan University;   Jiangxi Provincial Cancer Hospital;   The First Affiliated Hospital of Kunming Medical College;   Loudi Central Hospital;   ZhuZhou Central Hospital;   Xiangtan Central Hospital;   First People's Hospital of Chenzhou;   Yueyang Central Hospital;   Yongzhou Central Hospital;   The First Affiliated Hospital of University of South China;   Hunan Provincial People's Hospital;   Shaoyang Central Hospital;   Yiyang Central Hospital;   Changsha Central Hospital;   The first people's hospital of Guiyang;   Wuhan Union Hospital, China;   Renmin Hospital of Wuhan University;   The First People's Hospital of Changde;   Zhuzhou Second Hospital;   First Hospital of Changsha;   Hengyang Central Hospital;   Huaihua first people's Hospital;   The First People's Hospital of Xiangtan;   University of South China Affiliated Nanhua Hospital;   Xiangxi Autonomous Prefecture People's Hospital;   People's Hospital of Zhangjiajie;   Second People's Hospital Of Huaihua;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   The Third Hospital of Changsha;   Xiangya Changde Hospital;   Changsha County first People's Hospital;   Hunan Provincial Straight Hospital of Traditional Chinese Medicine;   Liuyang Hospital of traditional Chinese Medicine

Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C

Condition:   Niemann-Pick Disease, Type C
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)