Precision Health Clinical Trials

The Belgian Molecular Profiling Program of Metastatic Cancer for Clinical Decision and Treatment Assignment

Condition:   Metastatic Cancer
Sponsor:   The Belgian Society of Medical Oncology

Peptide-based Immunization for Colon- and and Pancreas-carcinoma

Conditions:   Colon Neoplasm;   Colon Adenocarcinoma;   Colon Cancer;   Colo-rectal Cancer;   Rectal Cancer;   Rectal Neoplasms;   Rectal Adenocarcinoma;   Rectal Tumors;   Pancreatic Cancer;   Pancreas Cancer;   Pancreatic Neoplasms;   Pancreatic Adenocarcinoma
Intervention:   Diagnostic Test: Analysis of molecular tumor particularities and neoepitopes
Sponsor:   Centogene AG Rostock
Not yet recruiting

Non-invasive Liquid Biopsy Analysis of Epigenomics Signatures in Multiple Cancer Types

Condition:   Cancer of Various Organs
Intervention:   Diagnostic Test: Non-invasive Liquid Biospy
Sponsor:   Bluestar Genomics Inc.

DNA Methylation in Allogeneic Hematopoietic Stem Cell Transplantation.

Conditions:   Aging;   Stem Cell Transplant Complications
Sponsors:   St. Orsola Hospital;   Mariarosaria Sessa, MD;   Mario Arpinati, MD;   Francesco Barbato, MD

Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

Conditions:   Overweight;   Type 2 Diabetes Mellitus;   Type 1 Diabetes Mellitus
Interventions:   Other: Lifestyle Intervention;   Other: No Intervention
Sponsor:   Joslin Diabetes Center

Cell Free DNA in Cardiac Sarcoidosis

Conditions:   Sarcoidosis With Myocarditis;   Sarcoidosis;   Healthy;   ST Elevation Myocardial Infarction
Intervention:   Diagnostic Test: cell free DNA
Sponsor:   Nabeel Hamzeh
Not yet recruiting

Contribution of High Throughput RNA Sequencing Combined With Sequencing of Whole Genomes in the Diagnosis of Intellectual Disability

Conditions:   Patients With Intellectual Disabilities Without an Obvious Clinical Diagnosis;   Patients With Normal Array CGH and Previous Negative Genetic Investigations (WES-solo or WES-trio)
Interventions:   Biological: Patient blood sampling;   Biological: Parents blood sampling
Sponsor:   Centre Hospitalier Universitaire Dijon

Integrative Sequencing In Germline and Hereditary Tumours

Conditions:   Hereditary Cancer Syndrome;   High-Risk;   Mutation;   Germline Mutation
Sponsor:   University Health Network, Toronto

Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors

Conditions:   Mismatch Repair Proficient Colorectal Cancer;   Pancreatic Adenocarcinoma;   Leiomyosarcoma
Interventions:   Biological: Durvalumab;   Drug: Olaparib;   Drug: Cediranib
Sponsors:   University Health Network, Toronto;   AstraZeneca

South-seq: Deoxyribonucleic Acid (DNA) Sequencing for Newborn Nurseries in the South

Condition:   Whole Genome Sequencing
Interventions:   Behavioral: Genetic Counselor;   Behavioral: Trained Healthcare Provider
Sponsors:   University of Alabama at Birmingham;   University of Mississippi Medical Center;   HudsonAlpha Institute for Biotechnology;   Woman's Hospital, Louisiana;   Children's Hospital of New Orleans
Not yet recruiting