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Clinical Trials

NCT04124718 - Genetic and Environmental Factors in Adults With Low and High Caries Experience

Genetic and Environmental Factors in Adults With Low and High Caries Experience
Conditions:   Low Caries Experience;   High Caries Experience
Intervention:   Genetic: high caries experience
Sponsor:   Recep Tayyip Erdogan University Training and Research Hospital
Recruiting
Pub Date: 
Friday, October 11, 2019 - 9:00am
Study URL: 
https://clinicaltrials.gov/ct2/show/NCT04124718?term=genomics%20DNA&%3Brecrs=abc

NCT03020381 - Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study

Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study
Conditions:   Gait Apraxia;   Mild Cognitive Impairment;   Subjective Cognitive Impairment;   Cerebral Atrophy;   Alzheimer Disease;   Dementia
Intervention:  
Sponsor:   Lawson Health Research Institute
Recruiting
Pub Date: 
Friday, January 13, 2017 - 10:00am
Study URL: 
https://clinicaltrials.gov/ct2/show/NCT03020381?term=genomics%20DNA&%3Brecrs=abc

NCT05633381 - Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working
Conditions:   Locally Advanced Leiomyosarcoma;   Metastatic Leiomyosarcoma;   Stage III Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IV Uterine Corpus Leiomyosarcoma AJCC v8;   Unresectable Leiomyosarcoma;   Uterine Corpus Leiomyosarcoma
Interventions:   Drug: Olaparib;   Drug: Temozolomide;   Drug: Trabectedin;   Drug: Pazopanib
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Recruiting
Pub Date: 
Thursday, December 1, 2022 - 10:00am
Study URL: 
http://classic.clinicaltrials.gov/ct2/show/NCT05633381?term=genomics%20DNA&%3Brecrs=abc

NCT02720679 - Investigation of the Genetics of Hematologic Diseases

Investigation of the Genetics of Hematologic Diseases
St. Jude Children's Research Hospital

The purpose of this study is to collect and store samples and health information for current and future research to learn more about the causes and treatment of blood diseases. This is not a therapeutic or diagnostic protocol for clinical purposes. Blood, bone marrow, hair follicles, nail clippings, urine, saliva and buccal swabs, left over tissue, as well as health information will be used to study and learn about blood diseases by using genetic and/or genomic research. In general, genetic research studies specific genes of an individual; genomic research studies the complete genetic makeup of an individual.

It is not known why many people have blood diseases, because not all genes causing these diseases have been found. It is also not known why some people with the same disease are sicker than others, but this may be related to their genes. By studying the genomes in individuals with blood diseases and their family members, the investigators hope to learn more about how diseases develop and respond to treatment which may provide new and better ways to diagnose and treat blood diseases.

NCT03838588 - The Tracking Molecular Evolution for NSCLC (T-MENC) Study

The Tracking Molecular Evolution for NSCLC (T-MENC) Study
Geneplus-Beijing Co. Ltd.
Tumor genomic clonal evolution assessed with liquid biopsy of stage IB,II and IIIA non-small cell lung cancer patients after getting radical resection. Plasma circulating tumor DNA (ctDNA) analysis detects molecule residual disease and predicts recurrence in patients. The concordance of the relative abundance of mutations in plasma ctDNA with cancer recurrence.

NCT02791880 - Acute Kidney Injury Genomics and Biomarkers in TAVR Study

Acute Kidney Injury Genomics and Biomarkers in TAVR Study
University of Texas Southwestern Medical Center
In the last decade, transcatheter aortic valve replacement (TAVR) has become an increasingly utilized alternative procedure for replacing a stenotic aortic valve. This study collects clinical information, DNA, blood and urine samples (throughout procedural hospitalization) in order to investigate the incidence of acute kidney injury (AKI) in patients undergoing TAVR and to identify key clinical and procedural predictors of AKI. This study seeks to identify blood and urine biomarkers that can be used for early detection of AKI around the time of the procedure. The study seeks to assess for novel genetic variants associated with development of AKI after TAVR. Finally the study seeks to assess for novel genetic variants and biomarkers that are associated with adverse cardiovascular events after TAVR and to further explore how these events may inter-relate with acute kidney injury.

NCT04166305 - Drug Resistant Epilepsy: Clinical and Genetic Study

Drug Resistant Epilepsy: Clinical and Genetic Study
Mansoura University Hospital
This study is to identify the clinical criteria of drug resistant epilepsy and to explore whether SCN1A c.3184 A/G (rs2298771) and ccl2(rs1024611) polymorphisms could serve as genetic based biomarkers to predict drug resistance among epileptic patient.