Precision Health Clinical Trials

Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam

Conditions:   Whole Exome Sequencing;   Epileptic Encephalopathy
Sponsors:   Number 2 Children's Hospital, Ho Chi Minh City;   Swiss National Science Foundation;   School of Medicine - Vietnam National University at Ho Chi Minh city;   University of Medicine and Pharmacy at Ho Chi Minh City;   University Hospital, Geneva

Genomic and Dietary Aspects in Gastric Cancer Risk

Condition:   Gastric Cancer
Sponsors:   Fondazione Policlinico Universitario Agostino Gemelli IRCCS;   University of Bologna
Not yet recruiting

Translational-Omics in Aortic Stenosis (TOmAS) Biobank

Conditions:   Cardiovascular Diseases;   Aortic Valve Stenosis
Intervention:   Other: Genetics
Sponsor:   McGill University Health Centre/Research Institute of the McGill University Health Centre

National Register of Actionable Mutations

Condition:   Solid Tumours in Advanced Stages
Sponsors:   Federation of Italian Cooperative Oncology Groups;   Roche Pharma AG;   AstraZeneca;   Bayer;   Bristol-Myers Squibb;   Janssen, LP;   Takeda;   Amgen;   Daiichi Sankyo, Inc.;   Eli Lilly and Company;   Novartis;   Clinical Research Technology S.r.l.

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

Conditions:   Bile Duct Adenocarcinoma;   Fanconi Anemia Complementation Group Gene Mutation;   Metastatic Bile Duct Carcinoma;   PTEN Gene Deletion
Interventions:   Procedure: Biospecimen Collection;   Procedure: Computed Tomography;   Procedure: Magnetic Resonance Imaging;   Drug: Olaparib
Sponsors:   Academic and Community Cancer Research United;   National Cancer Institute (NCI)

Impact of Immuno-Oncologic Agent on Neoadjuvant Chemotherapy in Triple Negative Breast Cancer

Conditions:   Triple Negative Breast Cancer;   Neoadjuvant Chemotherapy;   Pembrolizumab;   Tumor Microenvironment
Intervention:   Genetic: Visium, Whole Genome Sequencing(WGS)/Whole Transcriptome Sequencing(WTS)
Sponsor:   Samsung Medical Center

Clinical Presentation of Genetic Disorders in Patients Attending Genetic Outpatient Clinic of Assiut University Children Hospital

Condition:   Genetic Disease Clinical Presentation in Patients Attending Genetics Outpatient Clinic of Assiut University Children Hospital
Sponsor:   Assiut University
Not yet recruiting

Detection and Risk Stratification in Veterans Presenting With Microscopic Hematuria

Condition:   Urothelial Carcinoma
Intervention:   Diagnostic Test: Cxbladder urine test
Sponsor:   Pacific Edge Limited
Not yet recruiting

Feasibility and Impact of Liquid Biopsy Genomic Profiling on Treatment Patients With Metastatic Prostate Cancer in Spain (SOLTI-2102)

Condition:   Metastatic Prostate Cancer
Interventions:   Genetic: Liquid Biopsy;   Genetic: Archival Tumor DNA sequencing
Sponsors:   SOLTI Breast Cancer Research Group;   Pfizer;   AstraZeneca;   Merck Sharp & Dohme LLC;   Advanced Accelerator Applications;   Astellas Pharma Inc;   Guardant Health, Inc.

Decoding the Genetic Landscape of Skeletal Diseases

Conditions:   Genetic Skeletal Diseases;   Skeletal Dysplasia;   Molecular Causes;   Skeletal Disorder
Sponsors:   Karolinska Institutet;   Karolinska University Hospital;   Göteborg University