Precision Health Clinical Trials

Health in Aging, Neurodegenerative Diseases and Dementias In Ontario

Conditions:   Neuro-Degenerative Disease;   Dementia
Intervention:  
Sponsors:   Ontario Neurodegeneration Disease Research Initiative;   Ontario Brain Institute
Recruiting

COVID-19 Antibody Responses In Cystic Fibrosis: CAR-CF

Conditions:   Cystic Fibrosis;   Covid19
Intervention:  
Sponsors:   Medical University Innsbruck;   Queen's University, Belfast;   European Cystic Fibrosis Society - Clinical Trial Network;   Cystic Fibrosis Foundation
Recruiting

The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy

Conditions:   Varicose Veins;   Varicose Veins of Lower Limb;   Chronic Venous Insufficiency;   Varicose; Vessel
Interventions:   Diagnostic Test: Advanced ultrasound measurements (Duplex ultrasound (DUS) and Vector flow imaging (VFI);   Other: Clinical interventions and procedures
Sponsor:   Imperial College London
Not yet recruiting

Adverse Childhood Experiences in Alcohol Use Disorder

Conditions:   Alcohol Use Disorder;   Trauma, Psychological
Intervention:   Other: No intervention
Sponsors:   Central Institute of Mental Health, Mannheim;   German Research Foundation
Not yet recruiting

The Neuroimage Study of the Neuromuscular Disorders.

Condition:   Neuromuscular Diseases
Interventions:   Diagnostic Test: Neuromuscular ultrasound;   Diagnostic Test: Muscle MRI;   Diagnostic Test: Nerve conduction studies and autonomic function tests;   Diagnostic Test: Quantitative sensory test;   Diagnostic Test: Skin biopsy;   Diagnostic Test: Muscle and nerve biopsy;   Diagnostic Test: Genomics, transcriptome, and proteomics;   Diagnostic Test: Laboratory of blood chemical substances, metals and endocrine profiles;   Diagnostic Test: Contact heat evoked potentials;   Diagnostic Test: Nerve excitability study;   Diagnostic Test: Transcranial magnetic stimulation (TMS);   Diagnostic Test: fMRI acquisition and image analysis
Sponsor:   National Taiwan University Hospital
Recruiting

Biology and Genetics of Smouldering Myeloma

Conditions:   Smouldering Myeloma;   MGUS;   Multiple Myeloma
Intervention:   Other: No intervention
Sponsors:   University College, London;   Cancer Research UK
Recruiting

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Conditions:   Mitochondrial Myopathies;   Mitochondrial DNA Mutation;   Mitochondrial Diseases;   Chronic Progressive External Ophthalmoplegia With Myopathy;   Kearns-Sayre Syndrome
Intervention:  
Sponsors:   Mayo Clinic;   Casimir, LLC;   Astellas Pharma Inc
Not yet recruiting

Safety, Pharmacokinetics and Anti-tumor Activity of RP12146, a PARP Inhibitor, in Patients With Locally Advanced or Metastatic Solid Tumors

Conditions:   Solid Tumor;   Extensive-stage Small-cell Lung Cancer;   Locally Advanced Breast Cancer;   Metastatic Breast Cancer;   Platinum-sensitive Ovarian Cancer;   Platinum-Sensitive Fallopian Tube Carcinoma;   Platinum-Sensitive Peritoneal Cancer
Intervention:   Drug: RP12146
Sponsor:   Rhizen Pharmaceuticals SA
Recruiting

Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis

Condition:   Tuberculosis, Multidrug-Resistant
Intervention:   Diagnostic Test: Targeted sequencing using the GenoScreen Deeplex assay
Sponsors:   University of Cape Town;   University of Stellenbosch;   Ospedale San Raffaele;   Stichting Katholieke Universiteit;   University of Cape Town Lung Institute
Not yet recruiting

Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience

Conditions:   Neurodevelopmental Disabilities;   Emotional Regulation;   Epigenetics;   Parental Factors
Interventions:   Diagnostic Test: DNA methylation analysis;   Diagnostic Test: Proteomics analysis;   Diagnostic Test: Still Face Paradigm
Sponsor:   IRCCS Eugenio Medea
Recruiting

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