Precision Health Clinical Trials

Retrospective Comparative in Vitro Case-controlled Study of the Liquid Biopsy Test System in Women With Breast Cancer

Condition:   Breast Neoplasm Female
Intervention:   Diagnostic Test: ARNA Breast
Sponsors:   ARNA Genomics US Inc.;   BIOMARKER-RU
Recruiting

Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Conditions:   Autologous Stem Cell Transplantation;   Allogeneic Stem Cell Transplantation;   Cellular Therapy;   Marrow Toxic Injury
Intervention:  
Sponsor:   Center for International Blood and Marrow Transplant Research
Recruiting

Genetic Variants Affecting the Clinical Severity of Beta Thalassemia

Condition:   Beta Thalassemia
Intervention:   Diagnostic Test: Hematological Analysis and Genetical Analysis
Sponsors:   Nanfang Hospital of Southern Medical University;   303rd Hospital of the People's Liberation Army;   Liuzhou Municipal Maternity and Child Healthcare Hospital;   Zhuhai Municipal Maternal and Child Healthcare Hospital;   Dong Guan Maternal and Child Health Hospital
Recruiting

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Conditions:   Acute Leukemia of Ambiguous Lineage in Relapse;   Acute Myeloid Leukemia, in Relapse;   Refractory Acute Leukemia of Ambiguous Lineage;   Refractory Acute Myeloid Leukemia
Interventions:   Drug: Venetoclax;   Drug: Selinexor;   Drug: Cytarabine;   Drug: Fludarabine;   Biological: Filgrastim;   Drug: Methotrexate;   Drug: methotrexate/hydrocortisone/cytarabine
Sponsors:   St. Jude Children's Research Hospital;   Karyopharm Therapeutics Inc;   AbbVie;   Gateway for Cancer Research
Recruiting

In Vitro Study of the Liquid Biopsy Test System of the Diagnostic Value, in Women With Various Forms of Breast Cancer

Condition:   Breast Neoplasms
Intervention:   Diagnostic Test: ARNA Breast
Sponsors:   ARNA Genomics US Inc.;   BIOMARKER-RU
Not yet recruiting

From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Biological sample collection
Sponsor:   Nantes University Hospital
Recruiting

Genomic Analysis of Families With a History of Discordant Cancers

Condition:   Discordant Cancers
Interventions:   Genetic: WES via Illumina NextSeq 550 sequencing system;   Diagnostic Test: Blood Draw;   Diagnostic Test: Skin biopsy;   Diagnostic Test: Saliva Sample
Sponsor:   Case Comprehensive Cancer Center
Not yet recruiting

Clinical Application of Non-invasive PGT-A

Condition:   Genetic Testing
Interventions:   Diagnostic Test: PGT-A;   Diagnostic Test: non-invasive PGT-A
Sponsors:   Kaohsiung Veterans General Hospital.;   Sofiva Genomics Co., Ltd.
Recruiting

Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual Triple Negative Breast Cancer

Conditions:   Breast Cancer;   Triple Negative Breast Cancer
Interventions:   Drug: Capecitabine;   Drug: Talazoparib;   Drug: Atezolizumab;   Drug: Inavolisib;   Other: Treatment of Choice
Sponsors:   Bryan Schneider, MD;   Genentech, Inc.;   Pfizer;   Foundation Medicine;   Indiana University;   Epic Sciences;   Vera Bradley Foundation for Breast Cancer Research
Recruiting

Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC

Condition:   High Grade Ovarian Serous Adenocarcinoma
Interventions:   Genetic: WGS and RNA sequencing;   Genetic: circulating tumor DNA (ctDNA);   Diagnostic Test: FDG PET/CT imaging
Sponsors:   Turku University Hospital;   University of Helsinki
Recruiting

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