Precision Health Clinical Trials

Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort

Conditions:   Developmental Disability;   Intellectual Disability;   Autism Spectrum Disorder;   Congenital Anomaly;   Fragile X Syndrome;   Facioscapulohumeral Muscular Dystrophy 1
Intervention:   Other: Standard of care genetic testing group
Sponsors:   Bionano Genomics;   University of Rochester;   Columbia University;   Greenwood Genetic Center;   Praxis Genomics;   Augusta University;   Medical College of Wisconsin;   University of Iowa

Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities. CHROmosome MAPping and Sequencing (CHROMAPS)

Conditions:   Infertility;   Intellectual Disability;   Malformation
Interventions:   Genetic: Optical Genome Mapping (Bionano®);   Genetic: Longread sequencing (Nanopore®)
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting

Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians

Condition:   Pharmacogenomics
Intervention:   Drug: Indapamide 1.5 MG SR
Sponsor:   Ain Shams University
Not yet recruiting

The Hong Kong Diabetes Biobank

Conditions:   Diabetes Mellitus;   Type 2 Diabetes;   Type 1 Diabetes;   Diabetic Nephropathies;   Diabetic Kidney Disease;   Diabetic Angiopathies;   Cardiovascular Diseases;   Coronary Heart Disease;   Diabetic Retinopathy;   Stroke;   Diabetes
Sponsor:   Chinese University of Hong Kong

Comparison of EPM-IX to Currently Used Specimen Transportation and Extraction Devices ( CGI-EPM-IX )

Condition:   SARS-CoV-2
Intervention:   Diagnostic Test: Enhanced Preservation Media (EPM-IX)
Sponsor:   Convergent Genomics, Inc.

Prephage - Faecal Bacteriophage Transfer for Enhanced Gastrointestinal Tract Maturation in Preterm Infants - Donor Study

Conditions:   Feeding Patterns;   Microbial Colonization
Sponsors:   Rigshospitalet, Denmark;   Lise Aunsholt, Neonatologist, Clinical Professor

Tempus Sculptor Study: Small Cell Lung Cancer (SCLC) Observational Study

Condition:   Small Cell Lung Cancer
Intervention:   Other: Observation
Sponsors:   Tempus Labs;   AstraZeneca

Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Condition:   Solid Tumors
Interventions:   Drug: Entrectinib;   Drug: Alectinib;   Drug: Atezolizumab;   Drug: Ipatasertib;   Drug: Trastuzumab emtansine;   Drug: Idasanutlin;   Drug: Inavolisib;   Drug: Belvarafenib;   Drug: Pralsetinib
Sponsor:   Hoffmann-La Roche

Artificial Intelligence for Help Non-Small Cell Lung Cancer: Measure Cancer Biology and Treatment Response Via Imaging

Condition:   Non Small Cell Lung Cancer
Intervention:   Procedure: Liquid biopsy
Sponsors:   OncoRadiomics;   University Hospital, Antwerp
Not yet recruiting

Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls

Conditions:   Preterm Birth;   Parent-Child Relations;   Epigenetics
Interventions:   Diagnostic Test: DNA methylation of target genes;   Diagnostic Test: EEG acquisition
Sponsor:   IRCCS Eugenio Medea