Precision Health Clinical Trials

Development of Free DNA Multi-target Methylated PCR for Auxiliary Diagnosis of Gastric Cancer

Condition:   Stomach Cancer
Intervention:   Other: No intervention
Sponsors:   Singlera Genomics Inc.;   Fudan University

Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)

Condition:   Early-stage Breast Cancer
Interventions:   Drug: Atezolizumab 1200 mg in 20 ML Injection;   Drug: Inavolisib;   Drug: Ipatasertib;   Drug: Olaparib;   Drug: Sacituzumab govitecan;   Drug: Trastuzumab/pertuzumab
Sponsor:   German Cancer Research Center

Spatial Analysis of Host-parasite Interactions in Cutaneous Leishmaniasis in Ethiopia

Condition:   Cutaneous Leishmaniases
Interventions:   Diagnostic Test: skin biopsy;   Diagnostic Test: venous blood sample (plasma, PBMC, WB);   Genetic: venous blood sample (HLA);   Genetic: skin slit
Sponsors:   Institute of Tropical Medicine, Belgium;   University of Gondar;   Wollo University;   University of York;   Maastricht University;   University Hospital, Antwerp

Genetic Aspects of Vaginal Aging

Condition:   Genitourinary Agents
Sponsors:   Żelazna Medical Centre, LLC;   Laboratory of Genetics and Human Genomics, University of Gdańsk

Patient Derived Preclinical Models

Condition:   Cancer
Interventions:   Procedure: Tissue Collection;   Diagnostic Test: Blood Collection;   Diagnostic Test: Buccal Swab
Sponsor:   Mayo Clinic

An Observational Cohort Study to Obese Patients With Weight Cycling

Conditions:   Weight Cycling;   Obesity
Sponsor:   Peking Union Medical College Hospital

Chromosomal Instability in Ovarian Cancer

Conditions:   Epithelial Ovarian Cancer;   High-grade Serous Ovarian Carcinoma;   Chromosomal Instability;   Somatic Copy Number Distortion;   Survival Outcomes;   Minimal Residual Lesions;   Progression-free Survival;   Overall Survival
Intervention:   Diagnostic Test: Testing for chromosomal instability (CIN)
Sponsor:   Lei Li

Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort

Conditions:   Developmental Disability;   Intellectual Disability;   Autism Spectrum Disorder;   Congenital Anomaly;   Fragile X Syndrome;   Facioscapulohumeral Muscular Dystrophy 1
Intervention:   Other: Standard of care genetic testing group
Sponsors:   Bionano Genomics;   University of Rochester;   Columbia University;   Greenwood Genetic Center;   Praxis Genomics;   Augusta University;   Medical College of Wisconsin;   University of Iowa

Omics-based Predictors of NAFLD/Potential NASH

Conditions:   Non-Alcoholic Fatty Liver Disease;   Non Alcoholic Steatohepatitis
Interventions:   Diagnostic Test: Genomics (DNA Extraction);   Diagnostic Test: Epi-genomics;   Diagnostic Test: Proteomics (Glycoproteomics);   Diagnostic Test: Salivary Metabolomics;   Behavioral: Individualized counselling for behavioural modification
Sponsor:   National Research Centre, Egypt
Not yet recruiting

Translational Immunodiagnostics in Stroke (TrImS)

Conditions:   Acute Ischemic Stroke;   Haemorrhagic Stroke;   Transient Ischemic Attacks;   Cardioembolic Stroke;   Large-Artery Atherosclerosis (Embolus/Thrombosis);   Small Vessel Disease;   Stroke of Other Determined Etiology;   Stroke of Undetermined Etiology;   Atrial Fibrillation;   Stroke of Anterior Cerebral Artery;   Stroke of Middle Cerebral Artery;   Stroke of Basilar Artery
Intervention:   Diagnostic Test: Biomarker blood draw and saliva collection
Sponsor:   The University of Hong Kong