Precision Health Clinical Trials
UW Undiagnosed Diseases Program
Conditions: Rare Diseases; Genetic Disease; Undiagnosed Disease
Intervention: Diagnostic Test: Trio Whole Genome Sequencing and Participant-Specific Research
Sponsors: University of Wisconsin, Madison; University of Wisconsin Center for Human Genomics and Precision Medicine
Recruiting
Intervention: Diagnostic Test: Trio Whole Genome Sequencing and Participant-Specific Research
Sponsors: University of Wisconsin, Madison; University of Wisconsin Center for Human Genomics and Precision Medicine
Recruiting
For more information, visit the Study URL.
Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics
Conditions: Biliary Tract Neoplasms; Gastric Cancer; Esophageal Squamous Cell Carcinoma; Colorectal Cancer; Gastrointestinal Stromal Tumors; Pancreatic Cancer; Neuroendocrine Tumors; Unknown Primary Cancer; Digestive Cancer
Interventions: Drug: FGFR Inhibitor, IDH1 Inhibitor, HER2 Inhibitor, PARP Inhibitor, BRAF Inhibitor, MEK Inhibitor, ICIs, EGFR-TKIs, NTRK-TKI, and et. al.; Drug: Other Therapy
Sponsors: Peking University; Hangzhou DIAN Medical Diagnostic Center Co., Ltd., China
Recruiting
Interventions: Drug: FGFR Inhibitor, IDH1 Inhibitor, HER2 Inhibitor, PARP Inhibitor, BRAF Inhibitor, MEK Inhibitor, ICIs, EGFR-TKIs, NTRK-TKI, and et. al.; Drug: Other Therapy
Sponsors: Peking University; Hangzhou DIAN Medical Diagnostic Center Co., Ltd., China
Recruiting
For more information, visit the Study URL.
Transcriptional and Immine Parameters of Response to Belinumab
Condition: Systemic Lupus Erythematosus
Intervention: Drug: Belimumab
Sponsor: Biomedical Research Foundation, Academy of Athens
Not yet recruiting
Intervention: Drug: Belimumab
Sponsor: Biomedical Research Foundation, Academy of Athens
Not yet recruiting
For more information, visit the Study URL.
Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer
Conditions: Biliary Tract Cancer; Cholangiocarcinoma; Gallbladder Cancer; Intrahepatic Cholangiocarcinoma; Perihilar Cholangiocarcinoma; Extrahepatic Cholangiocarcinoma; Hilar Cholangiocarcinoma; Distal Bile Duct Cancer
Intervention: Diagnostic Test: Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring
Sponsors: University of Washington; Natera, Inc.; SEngine Precision Medicine, Inc.
Recruiting
Intervention: Diagnostic Test: Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring
Sponsors: University of Washington; Natera, Inc.; SEngine Precision Medicine, Inc.
Recruiting
For more information, visit the Study URL.
Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
Conditions: Oropharyngeal Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Head and Neck Squamous Cell Carcinoma; Oropharynx Squamous Cell Carcinoma
Intervention:
Sponsors: UNC Lineberger Comprehensive Cancer Center; Mayo Clinic
Recruiting
Intervention:
Sponsors: UNC Lineberger Comprehensive Cancer Center; Mayo Clinic
Recruiting
For more information, visit the Study URL.
Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools
Condition: Developmental Disorders
Interventions: Genetic: genome-wide analyses; Genetic: Search for de novo mutations in paternal sperm samples
Sponsor: University Hospital, Rouen
Not yet recruiting
Interventions: Genetic: genome-wide analyses; Genetic: Search for de novo mutations in paternal sperm samples
Sponsor: University Hospital, Rouen
Not yet recruiting
For more information, visit the Study URL.
Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations
Conditions: Advanced Breast Carcinoma; Advanced Gastric Carcinoma; Advanced Malignant Solid Neoplasm; Advanced Ovarian Carcinoma; Advanced Pancreatic Carcinoma; Advanced Prostate Carcinoma; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Anatomic Stage IIIB Breast Cancer AJCC v8; Anatomic Stage IIIC Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Castration-Resistant Prostate Carcinoma; Clinical Stage III Gastric Cancer AJCC v8; Clinical Stage IV Gastric Cancer AJCC v8; Clinical Stage IVA Gastric Cancer AJCC v8; Clinical Stage IVB Gastric Cancer AJCC v8; HER2-Positive Breast Carcinoma; Metastatic Breast Carcinoma; Metastatic Gastric Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Ovarian Carcinoma; Metastatic Pancreatic Carcinoma; Metastatic Prostate Carcinoma; Pathologic Stage III Gastric Cancer AJCC v8; Pathologic Stage IIIA Gastric Cancer AJCC v8; Pathologic Stage IIIB Gastric Cancer AJCC v8; Pathologic Stage IIIC Gastric Cancer AJCC v8; Pathologic Stage IV Gastric Cancer AJCC v8; Platinum-Sensitive Ovarian Carcinoma; Postneoadjuvant Therapy Stage III Gastric Cancer AJCC v8; Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8; Prognostic Stage III Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8; Prognostic Stage IIIB Breast Cancer AJCC v8; Prognostic Stage IIIC Breast Cancer AJCC v8; Prognostic Stage IV Breast Cancer AJCC v8; Stage II Pancreatic Cancer AJCC v8; Stage IIA Pancreatic Cancer AJCC v8; Stage IIB Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage III Prostate Cancer AJCC v8; Stage IIIA Ovarian Cancer AJCC v8; Stage IIIA Prostate Cancer AJCC v8; Stage IIIA1 Ovarian Cancer AJCC v8; Stage IIIA2 Ovarian Cancer AJCC v8; Stage IIIB Ovarian Cancer AJCC v8; Stage IIIB Prostate Cancer AJCC v8; Stage IIIC Ovarian Cancer AJCC v8; Stage IIIC Prostate Cancer AJCC v8; Stage IV Ovarian Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IVA Ovarian Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Ovarian Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8
Interventions: Procedure: Biopsy; Drug: Talazoparib
Sponsor: National Cancer Institute (NCI)
Recruiting
Interventions: Procedure: Biopsy; Drug: Talazoparib
Sponsor: National Cancer Institute (NCI)
Recruiting
For more information, visit the Study URL.
ANXA5 M2 Haplotyping in IVF Patients and Embryos
Conditions: Infertility; Miscarriage, Recurrent; Pregnancy Complications
Intervention: Other: M2 Test
Sponsor: Genomic Prediction Inc.
Recruiting
Intervention: Other: M2 Test
Sponsor: Genomic Prediction Inc.
Recruiting
For more information, visit the Study URL.
Sub-study of the Essen Study Centre for the ENTAiER Trial
Conditions: Elderly Patients; Chronically Ill; Increased Risk of Falling
Interventions: Other: Eurythmy Therapy; Other: Tai Chi; Other: Standard Care
Sponsors: Universität Duisburg-Essen; Software AG Stiftung; Universität Freiburg
Not yet recruiting
Interventions: Other: Eurythmy Therapy; Other: Tai Chi; Other: Standard Care
Sponsors: Universität Duisburg-Essen; Software AG Stiftung; Universität Freiburg
Not yet recruiting
For more information, visit the Study URL.
Integrative Proteomic Characterization of Pancreatic Ductal Adenocarcinoma
Condition: Tumor Tissues and Non-tumor Tissues From PDAC Patients Were Used for Genomic and Transcriptome Sequencing Analysis and Proteomics and Phosphorylated Proteomics
Intervention: Other: No intervention
Sponsor: Ruijin Hospital
Not yet recruiting
Intervention: Other: No intervention
Sponsor: Ruijin Hospital
Not yet recruiting
For more information, visit the Study URL.