Official Title
Autophagy Dysfunction in Hidradenitis Suppurativa
Brief Title
Autophagy Dysfunction in Hidradenitis Suppurativa
Protocol ID
NCT05723757
Lead Sponsor
Association pour la Recherche Clinique et Immunologique
Brief Summary
The pathogenesis of HS is still poorly understood: the pilosebaceous tropism and the fact
that patients respond to combinations of antibiotics and/or immunosuppressive treatments
suggest the involvement of 3 factors that would be intimately linked: the presence of (i)
a microbial dysbiosis, (ii) a dysfunction of the pilosebaceous apparatus and (iii) an
inappropriate immune response. But how these 3 elements interact with each other remains
unestablished, with few studies that have analyzed them from a kinetic point of view.
Beyond a possible dysfunction of the pilosebaceous apparatus, we hypothesize a bacterial
dysbiosis in connection with abnormalities of autophagy function with secondary
development of an inappropriate immune response. Because of its functions of bacterial
clearance and activation of local immune response, a defect in the autophagic process may
be associated with the development of inflammatory pathologies related to microbial
dysbiosis. Crohn's disease (CD), an inflammatory pathology of the gastrointestinal tract
associated with intestinal dysbiosis, has been associated with alterations in autophagy,
with approximately 50% of patients having single nucleotide polymorphisms (SNPs)
associated with autophagy deficiency (Ellinghaus et al., 2013). The epidemiological
association of CD/HS, the presence of skin dysbiosis and a chronic inflammatory response
during HS, make us suspect a deficit of autophagic function in these patients, in a
similar way to what is observed during Crohn's disease.
The aim of this study is to analyze the frequency of 100 SNPs, reported to be associated
with autophagy deficiency, in a cohort of moderate-to-severe HS patients.
Enrollment Count
50 participants
Eligibility Criteria
Inclusion Criteria:
- Subject aged 18 to 65 years (included)
- Subject diagnosed with HS for at least 1 year
- Subject diagnosed with moderate-to-severe HS defined by HS PGA≥3
- Subject presenting an HS with inflammatory phenotype defined by the presence of
folliculitis, nodules and/or abcesses
- Subject suffering from at least 4 flares/year and presenting 5 active inflammatory
lesions (nodules and/or abcesses)
- Subject able to read, understand and give documented informed consent
- Subject willing and able to comply with the protocol requirements for the duration
of the study
- Subject with health insurance coverage according to local regulations
Exclusion Criteria:
- - Pregnancy or breast-feeding women
- Subject currently experiencing or having a history of other concomitant skin or
systemic inflammatory conditions that could constitute a bias (i.e. psoriasis,
Crohn's Disease, etc.)
- Subject with any additional condition that, in the opinion of the investigator, may
interfere with the assessment or put the subject at risk
- Linguistic or mentally incapacity to sign the consent form
- Subject protect by the law (adult under guardianship, or hospitalized in a public or
private institution for a reason other than study, or incarcerated)
- Subject in an exclusion period from a previous study or who is participating in
another clinical trial using a drug
Filters
Hidradenitis Suppurativa (HS)
NA
UNKNOWN
ADULT
OLDER_ADULT