Precision Health Clinical Trials

Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use

Conditions:   Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting

For more information, visit the Study URL.

Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their Patents

Conditions:   Fanconi Anemia;   Autosomal or Sex Linked Recessive Genetic Disease;   Bone Marrow Hematopoiesis Failure, Multiple Congenital Abnormalities, and Susceptibility to Neoplastic Diseases.;   Hematopoiesis Maintainance.
Interventions:   Genetic: human whole exome;   Genetic: whole genomic
Sponsor:   Xiaofan Zhu
Available

For more information, visit the Study URL.

Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations

Conditions:   Advanced Ovarian Cancer;   Primary Peritoneal Cancer;   Advanced Breast Cancer;   Advanced Solid Tumors
Intervention:   Drug: BMN 673
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

For more information, visit the Study URL.

Genome Sequencing of Human Cancer Tissues

Condition:   Cancer
Intervention:   Other: Cancer Treatment Options
Sponsor:   New Mexico Cancer Care Alliance
Recruiting

For more information, visit the Study URL.

Alcoholic Hepatitis: A Multicenter, Observational Study by the TREAT Consortium

Condition:   Alcoholic Hepatitis
Intervention:  
Sponsors:   Indiana University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

For more information, visit the Study URL.

Next Generation pErsonalized tX(Therapy) With Plasma DNA Trial-2 in Refractory Solid Tumors (The NEXT-2 Trial)

Conditions:   Metastatic Gastrointestinal Cancer;   Genitourinary Cancer
Intervention:  
Sponsor:   Samsung Medical Center
Recruiting

For more information, visit the Study URL.

Molecular-Guided Therapy for Childhood Cancer

Conditions:   Neuroblastoma;   Medulloblastoma;   Glioma;   Ependymoma;   Choroid Plexus Neoplasms;   Craniopharyngioma;   Dysembryoplastic Neuroepithelial Tumor;   Meningioma;   Primitive Neuroectodermal Tumors (PNETs);   Germ Cell Tumors;   Rhabdomyosarcoma;   Non-rhabdomyosarcoma;   Ewings Sarcoma;   Osteosarcoma;   Wilms Tumor;   Renal Cell Carcinoma;   Malignant Rhabdoid Tumor;   Clear Cell Sarcoma;   Liver Tumors
Intervention:   Device: Guided Therapy
Sponsors:   Giselle Sholler;   Translational Genomics Research Institute;   Dell, Inc.
Recruiting

For more information, visit the Study URL.

Establishment of NAFLD Cohort and Development of Fibrosis Markers

Condition:   Fibrosis of Liver
Interventions:   Procedure: Liver biopsy;   Device: ARFI;   Device: SWE;   Device: Transient elastography
Sponsor:   Seoul National University Boramae Hospital
Recruiting

For more information, visit the Study URL.

Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer

Conditions:   Recurrent Non-small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
Interventions:   Other: cytology specimen collection procedure;   Other: laboratory biomarker analysis
Sponsors:   Barbara Ann Karmanos Cancer Institute;   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

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