Precision Health Clinical Trials

Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use

Conditions:   Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting

Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their Patents

Conditions:   Fanconi Anemia;   Autosomal or Sex Linked Recessive Genetic Disease;   Bone Marrow Hematopoiesis Failure, Multiple Congenital Abnormalities, and Susceptibility to Neoplastic Diseases.;   Hematopoiesis Maintainance.
Interventions:   Genetic: human whole exome;   Genetic: whole genomic
Sponsor:   Xiaofan Zhu
Available

Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations

Conditions:   Advanced Ovarian Cancer;   Primary Peritoneal Cancer;   Advanced Breast Cancer;   Advanced Solid Tumors
Intervention:   Drug: BMN 673
Sponsor:   National Cancer Institute (NCI)
Recruiting

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Genome Sequencing of Human Cancer Tissues

Condition:   Cancer
Intervention:   Other: Cancer Treatment Options
Sponsor:   New Mexico Cancer Care Alliance
Recruiting

Alcoholic Hepatitis: A Multicenter, Observational Study by the TREAT Consortium

Condition:   Alcoholic Hepatitis
Intervention:  
Sponsors:   Indiana University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Next Generation pErsonalized tX(Therapy) With Plasma DNA Trial-2 in Refractory Solid Tumors (The NEXT-2 Trial)

Conditions:   Metastatic Gastrointestinal Cancer;   Genitourinary Cancer
Intervention:  
Sponsor:   Samsung Medical Center
Recruiting

Molecular-Guided Therapy for Childhood Cancer

Conditions:   Neuroblastoma;   Medulloblastoma;   Glioma;   Ependymoma;   Choroid Plexus Neoplasms;   Craniopharyngioma;   Dysembryoplastic Neuroepithelial Tumor;   Meningioma;   Primitive Neuroectodermal Tumors (PNETs);   Germ Cell Tumors;   Rhabdomyosarcoma;   Non-rhabdomyosarcoma;   Ewings Sarcoma;   Osteosarcoma;   Wilms Tumor;   Renal Cell Carcinoma;   Malignant Rhabdoid Tumor;   Clear Cell Sarcoma;   Liver Tumors
Intervention:   Device: Guided Therapy
Sponsors:   Giselle Sholler;   Translational Genomics Research Institute;   Dell, Inc.
Recruiting

Establishment of NAFLD Cohort and Development of Fibrosis Markers

Condition:   Fibrosis of Liver
Interventions:   Procedure: Liver biopsy;   Device: ARFI;   Device: SWE;   Device: Transient elastography
Sponsor:   Seoul National University Boramae Hospital
Recruiting

Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer

Conditions:   Recurrent Non-small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
Interventions:   Other: cytology specimen collection procedure;   Other: laboratory biomarker analysis
Sponsors:   Barbara Ann Karmanos Cancer Institute;   National Cancer Institute (NCI)
Recruiting

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