Precision Health Clinical Trials

The Neuroimage Study of the Neuromuscular Disorders.

Condition:   Neuromuscular Diseases
Interventions:   Diagnostic Test: Neuromuscular ultrasound;   Diagnostic Test: Muscle MRI;   Diagnostic Test: Nerve conduction studies and autonomic function tests;   Diagnostic Test: Quantitative sensory test;   Diagnostic Test: Skin biopsy;   Diagnostic Test: Muscle and nerve biopsy;   Diagnostic Test: Genomics, transcriptome, and proteomics;   Diagnostic Test: Laboratory of blood chemical substances, metals and endocrine profiles;   Diagnostic Test: Contact heat evoked potentials;   Diagnostic Test: Nerve excitability study;   Diagnostic Test: Transcranial magnetic stimulation (TMS);   Diagnostic Test: fMRI acquisition and image analysis
Sponsor:   National Taiwan University Hospital
Recruiting

For more information, visit the Study URL.

Adverse Childhood Experiences in Alcohol Use Disorder

Conditions:   Alcohol Use Disorder;   Trauma, Psychological
Intervention:   Other: No intervention
Sponsors:   Central Institute of Mental Health, Mannheim;   German Research Foundation
Recruiting

For more information, visit the Study URL.

Biology and Genetics of Smouldering Myeloma

Conditions:   Smouldering Myeloma;   MGUS;   Multiple Myeloma
Intervention:   Other: No intervention
Sponsors:   University College, London;   Cancer Research UK
Recruiting

For more information, visit the Study URL.

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Conditions:   Mitochondrial Myopathies;   Mitochondrial DNA Mutation;   Mitochondrial Diseases;   Chronic Progressive External Ophthalmoplegia With Myopathy;   Kearns-Sayre Syndrome
Intervention:  
Sponsors:   Mayo Clinic;   Casimir, LLC;   Astellas Pharma Inc
Recruiting

For more information, visit the Study URL.

Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis

Condition:   Tuberculosis, Multidrug-Resistant
Intervention:   Diagnostic Test: Targeted sequencing using the GenoScreen Deeplex assay
Sponsors:   University of Cape Town;   University of Stellenbosch;   Ospedale San Raffaele;   Stichting Katholieke Universiteit;   University of Cape Town Lung Institute
Not yet recruiting

For more information, visit the Study URL.

Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience

Conditions:   Neurodevelopmental Disabilities;   Emotional Regulation;   Epigenetics;   Parental Factors
Interventions:   Diagnostic Test: DNA methylation analysis;   Diagnostic Test: Proteomics analysis;   Diagnostic Test: Still Face Paradigm
Sponsor:   IRCCS Eugenio Medea
Recruiting

For more information, visit the Study URL.

Safety, Pharmacokinetics and Anti-tumor Activity of RP12146, a PARP Inhibitor, in Patients With Locally Advanced or Metastatic Solid Tumors

Conditions:   Solid Tumor;   Extensive-stage Small-cell Lung Cancer;   Locally Advanced Breast Cancer;   Metastatic Breast Cancer;   Platinum-sensitive Ovarian Cancer;   Platinum-Sensitive Fallopian Tube Carcinoma;   Platinum-Sensitive Peritoneal Cancer
Intervention:   Drug: RP12146
Sponsor:   Rhizen Pharmaceuticals SA
Recruiting

For more information, visit the Study URL.

Parkinson's Foundation PD GENEration Genetic Registry

Condition:   Parkinson's Disease
Intervention:   Device: Lab Assay for seven genetic variants for Parkinson's Disease
Sponsors:   Parkinson's Foundation;   Indiana University;   Fulgent Genetics;   The Parkinson Study Group
Recruiting

For more information, visit the Study URL.

Breast Cancer, Omics, and Precision Medicine

Condition:   Breast Cancer
Intervention:   Biological: Next Generation Sequencing and Network Analysis
Sponsor:   University of Campania "Luigi Vanvitelli"
Not yet recruiting

For more information, visit the Study URL.

Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

Conditions:   Whole Genome Sequencing;   Acute Myeloid Leukemia;   Myelodysplastic Syndromes
Intervention:   Device: ChromoSeq
Sponsor:   Washington University School of Medicine
Recruiting

For more information, visit the Study URL.

Pages