Precision Health Clinical Trials

The Neuroimage Study of the Neuromuscular Disorders.

Condition:   Neuromuscular Diseases
Interventions:   Diagnostic Test: Neuromuscular ultrasound;   Diagnostic Test: Muscle MRI;   Diagnostic Test: Nerve conduction studies and autonomic function tests;   Diagnostic Test: Quantitative sensory test;   Diagnostic Test: Skin biopsy;   Diagnostic Test: Muscle and nerve biopsy;   Diagnostic Test: Genomics, transcriptome, and proteomics;   Diagnostic Test: Laboratory of blood chemical substances, metals and endocrine profiles;   Diagnostic Test: Contact heat evoked potentials;   Diagnostic Test: Nerve excitability study;   Diagnostic Test: Transcranial magnetic stimulation (TMS);   Diagnostic Test: fMRI acquisition and image analysis
Sponsor:   National Taiwan University Hospital

Adverse Childhood Experiences in Alcohol Use Disorder

Conditions:   Alcohol Use Disorder;   Trauma, Psychological
Intervention:   Other: No intervention
Sponsors:   Central Institute of Mental Health, Mannheim;   German Research Foundation

Biology and Genetics of Smouldering Myeloma

Conditions:   Smouldering Myeloma;   MGUS;   Multiple Myeloma
Intervention:   Other: No intervention
Sponsors:   University College, London;   Cancer Research UK

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Conditions:   Mitochondrial Myopathies;   Mitochondrial DNA Mutation;   Mitochondrial Diseases;   Chronic Progressive External Ophthalmoplegia With Myopathy;   Kearns-Sayre Syndrome
Sponsors:   Mayo Clinic;   Casimir, LLC;   Astellas Pharma Inc

Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis

Condition:   Tuberculosis, Multidrug-Resistant
Intervention:   Diagnostic Test: Targeted sequencing using the GenoScreen Deeplex assay
Sponsors:   University of Cape Town;   University of Stellenbosch;   Ospedale San Raffaele;   Stichting Katholieke Universiteit;   University of Cape Town Lung Institute
Not yet recruiting

Emotional Regulation in Children With ND: the Role of Genomic Variation, Proteomic Patterns, and Early Experience

Conditions:   Neurodevelopmental Disabilities;   Emotional Regulation;   Epigenetics;   Parental Factors
Interventions:   Diagnostic Test: DNA methylation analysis;   Diagnostic Test: Proteomics analysis;   Diagnostic Test: Still Face Paradigm
Sponsor:   IRCCS Eugenio Medea

Safety, Pharmacokinetics and Anti-tumor Activity of RP12146, a PARP Inhibitor, in Patients With Locally Advanced or Metastatic Solid Tumors

Conditions:   Solid Tumor;   Extensive-stage Small-cell Lung Cancer;   Locally Advanced Breast Cancer;   Metastatic Breast Cancer;   Platinum-sensitive Ovarian Cancer;   Platinum-Sensitive Fallopian Tube Carcinoma;   Platinum-Sensitive Peritoneal Cancer
Intervention:   Drug: RP12146
Sponsor:   Rhizen Pharmaceuticals SA

Parkinson's Foundation PD GENEration Genetic Registry

Condition:   Parkinson's Disease
Intervention:   Device: Lab Assay for seven genetic variants for Parkinson's Disease
Sponsors:   Parkinson's Foundation;   Indiana University;   Fulgent Genetics;   The Parkinson Study Group

Breast Cancer, Omics, and Precision Medicine

Condition:   Breast Cancer
Intervention:   Biological: Next Generation Sequencing and Network Analysis
Sponsor:   University of Campania "Luigi Vanvitelli"
Not yet recruiting

Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

Conditions:   Whole Genome Sequencing;   Acute Myeloid Leukemia;   Myelodysplastic Syndromes
Intervention:   Device: ChromoSeq
Sponsor:   Washington University School of Medicine