Precision Health Clinical Trials

Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.

Conditions:   Congenital Heart Defects;   Dysmorphic Facial Features and Intellectual Developmental Disorder
Intervention:   Genetic: Epigenetic signatures
Sponsor:   University Hospital, Montpellier

Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

Conditions:   Metastatic Biliary Tract Carcinoma;   Metastatic Colorectal Carcinoma;   Metastatic Gastroesophageal Junction Adenocarcinoma;   Metastatic Malignant Digestive System Neoplasm;   Metastatic Pancreatic Adenocarcinoma;   Stage IV Colorectal Cancer AJCC v7;   Stage IV Pancreatic Cancer AJCC v6 and v7;   Stage IVA Colorectal Cancer AJCC v7;   Stage IVB Colorectal Cancer AJCC v7
Interventions:   Drug: Fluorouracil;   Drug: Irinotecan Sucrosofate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Rucaparib
Sponsors:   Academic and Community Cancer Research United;   National Cancer Institute (NCI)

Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)

Conditions:   Coronavirus Disease 2019 (COVID-19);   SARS-CoV-2
Interventions:   Procedure: Biological sample collection;   Procedure: Data Collection: Clinical Care Assessments
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Benaroya Research Institute;   Boston Children’s Hospital

NIAID Centralized Sequencing Protocol

Conditions:   Atopy;   Primary Immunodeficiency;   Autoimmunity;   Autoinflammation
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH)

Eating Disorders Genetics Initiative

Conditions:   Anorexia Nervosa;   Bulimia Nervosa;   Binge-Eating Disorder
Intervention:   Other: Eating disorder diagnosis group
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Mental Health (NIMH);   University of Otago;   University of Aarhus;   QIMR Berghofer Medical Research Institute

Genomic Markers for Measuring Breast Cancer Response to Neoadjuvant Chemotherapy

Conditions:   Breast Cancer;   Breast Neoplasms;   Cancer, Breast
Intervention:   Diagnostic Test: Genomic Markers (CTC/ctDNA)
Sponsor:   Sunnybrook Health Sciences Centre

Li-Fraumeni Syndrome/TP53 Biobank

Conditions:   Li-Fraumeni Syndrome;   Li-Fraumeni-Like Syndrome
Intervention:   Other: No Intervention
Sponsors:   Abramson Cancer Center of the University of Pennsylvania;   Children's Hospital of Philadelphia

DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Atrial Fibrillation
Intervention:   Other: DNA methylome
Sponsor:   University of Campania "Luigi Vanvitelli"

Luxembourgish Fiber Cohort

Conditions:   Dietary Fiber;   Gastrointestinal Microbiome;   Healthy Volunteers
Interventions:   Dietary Supplement: High Fiber Diet Intervention;   Dietary Supplement: Low Fiber Diet Intervention
Sponsors:   Luxembourg Institute of Health;   Centre Hospitalier du Luxembourg;   Integrated Biobank of Luxembourg;   Luxembourg Centre for Systems Biomedicine

Embryo Selection by Noninvasive Preimplantation Genetic Test

Conditions:   Infertility;   Chromosome Abnormality
Intervention:   Diagnostic Test: Non-invasive chromosome screening(NICS)
Sponsors:   Peking University Third Hospital;   Jinling Hospital,Nanjing University,School Medicine;   Hebei Maternity and Reproductive hospital;   Northwest Women's and Children's Hospital, Xi'an, Shaanxi;   The First Medical Center of Chinese People's Liberation Army General Hospital;   Shengjing Hospital;   First Affiliated Hospital, Sun Yat-Sen University;   Reproductive & Genetic Hospital of CITIC-Xiangya;   Yikon Genomics Company, Ltd;   Peking University Shenzhen Hospital;   The Second Hospital of Hebei Medical University;   West China Second Hospital of Sichuan University;   Second Affiliated Hospital of Wenzhou Medical University;   Third Affiliated Hospital of Zhengzhou University