Precision Health Clinical Trials

Different Susceptibility to SARS CoV-2 Infection Among Health Care Workers Highly Exposed to COVID-19.

Conditions:   Health Care Worker Patient Transmission;   Receptor Site Alteration;   Susceptibility, Disease;   Immune Response
Intervention:   Diagnostic Test: Susceptibility to infection
Sponsor:   Asociacion para el Estudio de las Enfermedades Infecciosas

A Study of ABI-H2158-containing Regimens in Participants With Chronic Hepatitis B Virus Infection

Condition:   Chronic Hepatitis B
Interventions:   Drug: ABI-H2158;   Drug: Placebo;   Drug: Entecavir (ETV)
Sponsor:   Assembly Biosciences

A Study to Determine Frequency of DNA-repair Defects in Men With Metastatic Prostate Cancer

Condition:   Metastatic Prostate Cancer
Intervention:   Other: Saliva, Blood, or and/or Archival Tumor Tissue Collection and Analysis
Sponsor:   Janssen Research & Development, LLC

Better Delineation of YY1 Related Phenotype and Epigenetic Signatures.

Condition:   YY1 Related Disorder
Intervention:   Genetic: Epigenetic signatures
Sponsor:   University Hospital, Montpellier

Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.

Conditions:   Congenital Heart Defects;   Dysmorphic Facial Features and Intellectual Developmental Disorder
Intervention:   Genetic: Epigenetic signatures
Sponsor:   University Hospital, Montpellier

Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

Conditions:   Metastatic Biliary Tract Carcinoma;   Metastatic Colorectal Carcinoma;   Metastatic Gastroesophageal Junction Adenocarcinoma;   Metastatic Malignant Digestive System Neoplasm;   Metastatic Pancreatic Adenocarcinoma;   Stage IV Colorectal Cancer AJCC v7;   Stage IV Pancreatic Cancer AJCC v6 and v7;   Stage IVA Colorectal Cancer AJCC v7;   Stage IVB Colorectal Cancer AJCC v7
Interventions:   Drug: Fluorouracil;   Drug: Irinotecan Sucrosofate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Rucaparib
Sponsors:   Academic and Community Cancer Research United;   National Cancer Institute (NCI)

Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)

Conditions:   Coronavirus Disease 2019 (COVID-19);   SARS-CoV-2
Interventions:   Procedure: Biological sample collection;   Procedure: Data Collection: Clinical Care Assessments
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Benaroya Research Institute;   Boston Children’s Hospital

NIAID Centralized Sequencing Protocol

Conditions:   Atopy;   Primary Immunodeficiency;   Autoimmunity;   Autoinflammation
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH)

Eating Disorders Genetics Initiative

Conditions:   Anorexia Nervosa;   Bulimia Nervosa;   Binge-Eating Disorder
Intervention:   Other: Eating disorder diagnosis group
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Mental Health (NIMH);   University of Otago;   University of Aarhus;   QIMR Berghofer Medical Research Institute

Genomic Markers for Measuring Breast Cancer Response to Neoadjuvant Chemotherapy

Conditions:   Breast Cancer;   Breast Neoplasms;   Cancer, Breast
Intervention:   Diagnostic Test: Genomic Markers (CTC/ctDNA)
Sponsor:   Sunnybrook Health Sciences Centre