Precision Health Clinical Trials
The Oral Microbiome in OSCC
Condition: Oral Cancer
Interventions: Dietary Supplement: ProDentis Lozenge; Other: Placebo Lozenge
Sponsor: University of Iowa
Recruiting
Interventions: Dietary Supplement: ProDentis Lozenge; Other: Placebo Lozenge
Sponsor: University of Iowa
Recruiting
For more information, visit the Study URL.
Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
Conditions: Autologous Stem Cell Transplantation; Allogeneic Stem Cell Transplantation; Cellular Therapy; Marrow Toxic Injury
Intervention:
Sponsor: Center for International Blood and Marrow Transplant Research
Recruiting
Intervention:
Sponsor: Center for International Blood and Marrow Transplant Research
Recruiting
For more information, visit the Study URL.
Genetic Variants Affecting the Clinical Severity of Beta Thalassemia
Condition: Beta Thalassemia
Intervention: Diagnostic Test: Hematological Analysis and Genetical Analysis
Sponsors: Nanfang Hospital of Southern Medical University; 303rd Hospital of the People's Liberation Army; Liuzhou Municipal Maternity and Child Healthcare Hospital; Zhuhai Municipal Maternal and Child Healthcare Hospital; Dong Guan Maternal and Child Health Hospital
Recruiting
Intervention: Diagnostic Test: Hematological Analysis and Genetical Analysis
Sponsors: Nanfang Hospital of Southern Medical University; 303rd Hospital of the People's Liberation Army; Liuzhou Municipal Maternity and Child Healthcare Hospital; Zhuhai Municipal Maternal and Child Healthcare Hospital; Dong Guan Maternal and Child Health Hospital
Recruiting
For more information, visit the Study URL.
Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia
Conditions: Acute Leukemia of Ambiguous Lineage in Relapse; Acute Myeloid Leukemia, in Relapse; Refractory Acute Leukemia of Ambiguous Lineage; Refractory Acute Myeloid Leukemia
Interventions: Drug: Venetoclax; Drug: Selinexor; Drug: Cytarabine; Drug: Fludarabine; Biological: Filgrastim; Drug: Methotrexate; Drug: methotrexate/hydrocortisone/cytarabine
Sponsors: St. Jude Children's Research Hospital; Karyopharm Therapeutics Inc; AbbVie; Gateway for Cancer Research
Recruiting
Interventions: Drug: Venetoclax; Drug: Selinexor; Drug: Cytarabine; Drug: Fludarabine; Biological: Filgrastim; Drug: Methotrexate; Drug: methotrexate/hydrocortisone/cytarabine
Sponsors: St. Jude Children's Research Hospital; Karyopharm Therapeutics Inc; AbbVie; Gateway for Cancer Research
Recruiting
For more information, visit the Study URL.
In Vitro Study of the Liquid Biopsy Test System of the Diagnostic Value, in Women With Various Forms of Breast Cancer
Condition: Breast Neoplasms
Intervention: Diagnostic Test: ARNA Breast
Sponsors: ARNA Genomics US Inc.; BIOMARKER-RU
Not yet recruiting
Intervention: Diagnostic Test: ARNA Breast
Sponsors: ARNA Genomics US Inc.; BIOMARKER-RU
Not yet recruiting
For more information, visit the Study URL.
From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis
Condition: Multiple Sclerosis
Intervention: Other: Biological sample collection
Sponsor: Nantes University Hospital
Recruiting
Intervention: Other: Biological sample collection
Sponsor: Nantes University Hospital
Recruiting
For more information, visit the Study URL.
Genomic Analysis of Families With a History of Discordant Cancers
Condition: Discordant Cancers
Interventions: Genetic: WES via Illumina NextSeq 550 sequencing system; Diagnostic Test: Blood Draw; Diagnostic Test: Skin biopsy; Diagnostic Test: Saliva Sample
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Interventions: Genetic: WES via Illumina NextSeq 550 sequencing system; Diagnostic Test: Blood Draw; Diagnostic Test: Skin biopsy; Diagnostic Test: Saliva Sample
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
For more information, visit the Study URL.
Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual Triple Negative Breast Cancer
Conditions: Breast Cancer; Triple Negative Breast Cancer
Interventions: Drug: Capecitabine; Drug: Talazoparib; Drug: Pembrolizumab; Drug: Inavolisib
Sponsors: Bryan Schneider, MD; Genentech, Inc.; Pfizer; Foundation Medicine; Indiana University; Vera Bradley Foundation for Breast Cancer Research
Recruiting
Interventions: Drug: Capecitabine; Drug: Talazoparib; Drug: Pembrolizumab; Drug: Inavolisib
Sponsors: Bryan Schneider, MD; Genentech, Inc.; Pfizer; Foundation Medicine; Indiana University; Vera Bradley Foundation for Breast Cancer Research
Recruiting
For more information, visit the Study URL.
Clinical Application of Non-invasive PGT-A
Condition: Genetic Testing
Interventions: Diagnostic Test: PGT-A; Diagnostic Test: non-invasive PGT-A
Sponsors: Kaohsiung Veterans General Hospital.; Sofiva Genomics Co., Ltd.
Recruiting
Interventions: Diagnostic Test: PGT-A; Diagnostic Test: non-invasive PGT-A
Sponsors: Kaohsiung Veterans General Hospital.; Sofiva Genomics Co., Ltd.
Recruiting
For more information, visit the Study URL.
Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC
Conditions: High Grade Ovarian Serous Adenocarcinoma; High Grade Serous Carcinoma
Interventions: Genetic: WGS and RNA sequencing; Genetic: circulating tumor DNA (ctDNA); Diagnostic Test: FDG PET/CT imaging
Sponsors: Turku University Hospital; University of Helsinki
Recruiting
Interventions: Genetic: WGS and RNA sequencing; Genetic: circulating tumor DNA (ctDNA); Diagnostic Test: FDG PET/CT imaging
Sponsors: Turku University Hospital; University of Helsinki
Recruiting
For more information, visit the Study URL.