Precision Health Clinical Trials

The Oral Microbiome in OSCC

Condition:   Oral Cancer
Interventions:   Dietary Supplement: ProDentis Lozenge;   Other: Placebo Lozenge
Sponsor:   University of Iowa

Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Conditions:   Autologous Stem Cell Transplantation;   Allogeneic Stem Cell Transplantation;   Cellular Therapy;   Marrow Toxic Injury
Sponsor:   Center for International Blood and Marrow Transplant Research

Genetic Variants Affecting the Clinical Severity of Beta Thalassemia

Condition:   Beta Thalassemia
Intervention:   Diagnostic Test: Hematological Analysis and Genetical Analysis
Sponsors:   Nanfang Hospital of Southern Medical University;   303rd Hospital of the People's Liberation Army;   Liuzhou Municipal Maternity and Child Healthcare Hospital;   Zhuhai Municipal Maternal and Child Healthcare Hospital;   Dong Guan Maternal and Child Health Hospital

Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Conditions:   Acute Leukemia of Ambiguous Lineage in Relapse;   Acute Myeloid Leukemia, in Relapse;   Refractory Acute Leukemia of Ambiguous Lineage;   Refractory Acute Myeloid Leukemia
Interventions:   Drug: Venetoclax;   Drug: Selinexor;   Drug: Cytarabine;   Drug: Fludarabine;   Biological: Filgrastim;   Drug: Methotrexate;   Drug: methotrexate/hydrocortisone/cytarabine
Sponsors:   St. Jude Children's Research Hospital;   Karyopharm Therapeutics Inc;   AbbVie;   Gateway for Cancer Research

In Vitro Study of the Liquid Biopsy Test System of the Diagnostic Value, in Women With Various Forms of Breast Cancer

Condition:   Breast Neoplasms
Intervention:   Diagnostic Test: ARNA Breast
Sponsors:   ARNA Genomics US Inc.;   BIOMARKER-RU
Not yet recruiting

From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Biological sample collection
Sponsor:   Nantes University Hospital

Genomic Analysis of Families With a History of Discordant Cancers

Condition:   Discordant Cancers
Interventions:   Genetic: WES via Illumina NextSeq 550 sequencing system;   Diagnostic Test: Blood Draw;   Diagnostic Test: Skin biopsy;   Diagnostic Test: Saliva Sample
Sponsor:   Case Comprehensive Cancer Center
Not yet recruiting

Circulating Tumor DNA Enriched, Genomically Directed Post-neoadjuvant Trial for Patients With Residual Triple Negative Breast Cancer

Conditions:   Breast Cancer;   Triple Negative Breast Cancer
Interventions:   Drug: Capecitabine;   Drug: Talazoparib;   Drug: Pembrolizumab;   Drug: Inavolisib
Sponsors:   Bryan Schneider, MD;   Genentech, Inc.;   Pfizer;   Foundation Medicine;   Indiana University;   Vera Bradley Foundation for Breast Cancer Research

Clinical Application of Non-invasive PGT-A

Condition:   Genetic Testing
Interventions:   Diagnostic Test: PGT-A;   Diagnostic Test: non-invasive PGT-A
Sponsors:   Kaohsiung Veterans General Hospital.;   Sofiva Genomics Co., Ltd.

Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC

Conditions:   High Grade Ovarian Serous Adenocarcinoma;   High Grade Serous Carcinoma
Interventions:   Genetic: WGS and RNA sequencing;   Genetic: circulating tumor DNA (ctDNA);   Diagnostic Test: FDG PET/CT imaging
Sponsors:   Turku University Hospital;   University of Helsinki