Precision Health Clinical Trials

MUTYH-associated Polyposis

Condition:   MutYH-associated Polyposis
Intervention:   Genetic: Sanger sequencing method
Sponsor:   State Scientific Centre of Coloproctology, Russian Federation
Recruiting

For more information, visit the Study URL.

Development and Validation of a qPCR Cell Free DNA Assay as a Potential Biomarker for Predicting Early Non-response to Therapy in Metastatic Cancer

Conditions:   Metastatic Non-Small Cell Lung Carcinoma;   Metastatic Colorectal Cancer;   Metastatic Breast Cancer
Intervention:   Diagnostic Test: Blood-based cell-free cfDNA qPCR assay
Sponsor:   Cadex Genomics
Recruiting

For more information, visit the Study URL.

Olaparib and Temozolomide in Treating Patients With Advanced, Metastatic, or Unresectable Uterine Leiomyosarcoma

Conditions:   Stage III Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IV Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8;   Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8
Interventions:   Drug: Olaparib;   Drug: Temozolomide
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

Determination of the Feasibility of Tumoural Somatic Mutations Detection in Blood of Patients With Ovarian Cancer

Condition:   Ovarian Cancer
Intervention:   Diagnostic Test: HRD and BRCA mutations
Sponsor:   Institut de Cancérologie de Lorraine
Recruiting

For more information, visit the Study URL.

The Belgian Molecular Profiling Program of Metastatic Cancer for Clinical Decision and Treatment Assignment

Condition:   Metastatic Cancer
Intervention:  
Sponsor:   The Belgian Society of Medical Oncology
Recruiting

For more information, visit the Study URL.

Peptide-based Immunization for Colon- and and Pancreas-carcinoma

Conditions:   Colon Neoplasm;   Colon Adenocarcinoma;   Colon Cancer;   Colo-rectal Cancer;   Rectal Cancer;   Rectal Neoplasms;   Rectal Adenocarcinoma;   Rectal Tumors;   Pancreatic Cancer;   Pancreas Cancer;   Pancreatic Neoplasms;   Pancreatic Adenocarcinoma
Intervention:  
Sponsor:   CENTOGENE GmbH Rostock
Recruiting

For more information, visit the Study URL.

Non-invasive Liquid Biopsy Analysis of Epigenomics Signatures in Multiple Cancer Types

Condition:   Cancer of Various Organs
Intervention:   Diagnostic Test: Non-invasive Liquid Biospy
Sponsor:   Bluestar Genomics Inc.
Recruiting

For more information, visit the Study URL.

DNA Methylation in Allogeneic Hematopoietic Stem Cell Transplantation.

Conditions:   Aging;   Stem Cell Transplant Complications
Intervention:  
Sponsors:   IRCCS Azienda Ospedaliero-Universitaria di Bologna;   Mariarosaria Sessa, MD;   Mario Arpinati, MD;   Francesco Barbato, MD
Recruiting

For more information, visit the Study URL.

Impact of Metabolic Health on Sperm Epigenetic Marks in Humans

Conditions:   Overweight;   Type 2 Diabetes Mellitus;   Type 1 Diabetes Mellitus
Interventions:   Other: Lifestyle Intervention;   Other: No Intervention
Sponsor:   Joslin Diabetes Center
Recruiting

For more information, visit the Study URL.

Cell Free DNA in Cardiac Sarcoidosis

Conditions:   Sarcoidosis With Myocarditis;   Sarcoidosis;   Healthy;   ST Elevation Myocardial Infarction
Intervention:   Diagnostic Test: cell free DNA
Sponsor:   Nabeel Hamzeh
Recruiting

For more information, visit the Study URL.

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