Precision Health Clinical Trials

Regional Registry-based Biobank Development and Pharmacogenetic Analysis in Rheumatoid Arthritis

Condition:   Rheumatoid Arthritis
Intervention:   Other: Biobank creation and Pharmacogenetic analysis
Sponsors:   Istituto Ortopedico Rizzoli;   Regione Emilia Romagna - Italy within PRU-Liberati project
Recruiting

Genetic Testing for Men With Metastatic Prostate Cancer

Conditions:   Metastatic Prostate Carcinoma;   Stage IV Prostate Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8
Interventions:   Procedure: Biospecimen Collection;   Other: Genetic Counseling;   Other: Genetic Testing;   Other: Laboratory Biomarker Analysis;   Behavioral: Questionnaire
Sponsors:   University of Washington;   National Cancer Institute (NCI)
Recruiting

A Prospective Study to Evaluate the Consistency of Next-Generation Sequencing(NGS)-Panels by Using Malignant Hydrothorax Form NSCLC

Conditions:   Malignant Hydrothorax;   NSCLC
Intervention:   Diagnostic Test: in vitro NGS-panel
Sponsors:   Shanghai Chest Hospital;   Sinotech Genomics Co., Ltd;   Amoy Diagnostics Co., LTD;   Guangzhou Burning Rock Medical Examination Institute Co., Ltd.;   Geneplus-Beijing Co. Ltd.;   Berry Genomics Co., Ltd.
Recruiting

Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies

Conditions:   Sarcoma;   Endocrine Tumors;   Neuroblastoma;   Retinoblastoma;   Renal Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Recruiting

ctDNA as a Biomarker for Treatment Response in HNSCC

Condition:   Carcinoma, Squamous Cell of Head and Neck
Intervention:   Other: Blood draw
Sponsor:   The Netherlands Cancer Institute
Recruiting

Neoantigen DNA Vaccine in Combination With Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-Sensitive Prostate Cancer

Condition:   Metastatic Hormone-Sensitive Prostate Cancer
Interventions:   Biological: PROSTVAC-V;   Biological: PROSTVAC-F;   Drug: Nivolumab;   Drug: Ipilimumab;   Biological: Neoantigen DNA vaccine;   Device: TriGrid Delivery System;   Procedure: Tumor biopsy;   Procedure: Peripheral blood;   Procedure: Fecal samples;   Procedure: Leukapheresis
Sponsors:   Washington University School of Medicine;   Bristol-Myers Squibb;   Prostate Cancer Foundation;   BJH Foundation;   Bavarian Nordic
Recruiting

Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status

Conditions:   Colorectal Neoplasms;   Microsatellite Instability
Interventions:   Drug: temozolomide (induction),;   Biological: pembrolizumab (treatment)
Sponsor:   IFOM, The FIRC Institute of Molecular Oncology
Recruiting

Infant Peri-Exposure Prophylaxis to Prevent HIV-1 Transmission by Breastfeeding: Mechanisms & Safety

Condition:   Growth and Development
Intervention:  
Sponsor:   French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
Recruiting

Molecular Determinants of Coronaruy Artery Disease

Conditions:   Coronary Artery Disease;   Arteriovenous Malformations;   Myocardial Infarction
Intervention:  
Sponsors:   The Cleveland Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies

Conditions:   Lung Cancer;   Lymphoma
Interventions:   Genetic: DNA analysis;   Genetic: RNA analysis;   Genetic: gene expression analysis;   Genetic: polymorphism analysis;   Other: biologic sample preservation procedure;   Other: flow cytometry;   Other: medical chart review
Sponsors:   AIDS Malignancy Consortium;   National Cancer Institute (NCI);   The Emmes Company, LLC;   AIDS and Cancer Specimen Resource;   University of Arkansas
Recruiting

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