Precision Health Clinical Trials

Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies

Conditions:   Lung Cancer;   Lymphoma
Interventions:   Genetic: DNA analysis;   Genetic: RNA analysis;   Genetic: gene expression analysis;   Genetic: polymorphism analysis;   Other: biologic sample preservation procedure;   Other: flow cytometry;   Other: medical chart review
Sponsors:   AIDS Malignancy Consortium;   National Cancer Institute (NCI);   The Emmes Company, LLC;   AIDS and Cancer Specimen Resource;   University of Arkansas
Recruiting

For more information, visit the Study URL.

Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics

Conditions:   Smoking;   Diabetes
Intervention:   Procedure: Dental implant surgery
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Dental and Craniofacial Research (NIDCR);   National Center for Research Resources (NCRR)
Recruiting

For more information, visit the Study URL.

Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma or Rhabdoomyosarcoma

Conditions:   Ewing Sarcoma;   Rhabdomyosarcoma
Interventions:   Drug: Olaparib;   Drug: Temozolomide;   Drug: Irinotecan
Sponsor:   Massachusetts General Hospital
Recruiting

For more information, visit the Study URL.

Study to Determine the Efficacy of Regorafenib in Metastatic Colorectal Cancer Patients and to Discover Biomarkers

Condition:   Metastatic Colorectal Cancer
Intervention:   Drug: Regorafenib
Sponsors:   Gerald Batist;   Bayer;   Quebec Clinical Research Organization in Cancer
Recruiting

For more information, visit the Study URL.

Defining the Basis of Fibromuscular Dysplasia (FMD)

Conditions:   Fibromuscular Dysplasia;   Spontaneous Coronary Artery Dissection;   Cervical Artery Dissection
Intervention:  
Sponsor:   Icahn School of Medicine at Mount Sinai
Recruiting

For more information, visit the Study URL.

Randomized Controlled Trial of Genomically Directed Therapy in Patients With Triple Negative Breast Cancer

Conditions:   Malignant Neoplasm of Breast;   Breast Cancer
Interventions:   Drug: Genomically Directed Monotherapy;   Other: Observation/Standard Therapy
Sponsors:   Bryan Schneider, MD;   Hoosier Cancer Research Network;   Vera Bradley Foundation for Breast Cancer;   Walther Cancer Institute;   Strategic Research Initiative Grant through IUSCC
Recruiting

For more information, visit the Study URL.

Biomarkers for the Surgical Treatment of Rotator Cuff Tears

Condition:   Rotator Cuff Tears
Intervention:  
Sponsors:   Balgrist University Hospital;   RESORTHO foundation, Forchstrasse 340, 8008 Zürich, Switzerland
Recruiting

For more information, visit the Study URL.

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Conditions:   Non-Small Cell Lung Cancer;   Small Cell Lung Cancer;   Extrapulmonary Small Cell Cancer;   Pulmonary Neuroendocrine Tumors;   Thymic Epithelial Tumors
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Conditions:   Stage IIA Lung Cancer AJCC v8;   Stage IIB Lung Cancer AJCC v8;   Stage IIIA Lung Cancer AJCC v8;   Stage IIIB Lung Cancer AJCC v8
Interventions:   Procedure: Biospecimen Collection;   Drug: Carboplatin;   Drug: Cisplatin;   Other: Clinical Observation;   Procedure: Computed Tomography;   Drug: Crizotinib;   Other: Cytology Specimen Collection Procedure;   Drug: Erlotinib;   Drug: Gemcitabine Hydrochloride;   Biological: Nivolumab;   Drug: Paclitaxel;   Biological: Pembrolizumab;   Drug: Pemetrexed;   Drug: Pemetrexed Disodium;   Other: Placebo Administration;   Procedure: Positron Emission Tomography
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

The Role of Gut Microbiota in Hypertension

Condition:   Hypertension
Intervention:   Other: Stool Sample and Blood Sample
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

For more information, visit the Study URL.

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