Precision Health Clinical Trials

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations

Conditions:   Advanced Ovarian Cancer;   Primary Peritoneal Cancer;   Advanced Breast Cancer;   Advanced Solid Tumors
Intervention:   Drug: BMN 673
Sponsor:   National Cancer Institute (NCI)
Recruiting

Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their Patents

Conditions:   Fanconi Anemia;   Autosomal or Sex Linked Recessive Genetic Disease;   Bone Marrow Hematopoiesis Failure, Multiple Congenital Abnormalities, and Susceptibility to Neoplastic Diseases.;   Hematopoiesis Maintainance.
Interventions:   Genetic: human whole exome;   Genetic: whole genomic
Sponsor:   Xiaofan Zhu
Available

Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use

Conditions:   Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting

The Impact of Placental Factors on Fetal Intrauterine Growth and in Intrauterine Programming of the Metabolic Syndrome

Condition:   Normal Pregnancies
Intervention:  
Sponsor:   Meir Medical Center
Not yet recruiting

Genetic Risks for Bicuspid Aortic Valve Disease

Conditions:   Bicuspid Aortic Valve;   Unicuspid Aortic Valve
Intervention:  
Sponsor:   The University of Texas Health Science Center, Houston
Recruiting

Genomic Profiling in Cancer Patients

Conditions:   Solid Tumors;   Hematologic Cancers
Interventions:   Genetic: molecular profiling of tumors;   Genetic: Clinical Germline Analysis
Sponsor:   Memorial Sloan Kettering Cancer Center
Recruiting

AZD1775 for Advanced Solid Tumors

Conditions:   Neoplasms;   Lymphoma
Intervention:   Drug: MK-1775 (AZD1775)
Sponsor:   National Cancer Institute (NCI)
Recruiting

Biomarkers in Predicting Treatment Response in Samples From Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant Chemotherapy

Conditions:   Stage IA Non-small Cell Lung Cancer;   Stage IB Non-small Cell Lung Cancer;   Stage IIA Non-small Cell Lung Cancer;   Stage IIB Non-small Cell Lung Cancer;   Stage IIIA Non-small Cell Lung Cancer
Interventions:   Other: medical chart review;   Other: laboratory biomarker analysis
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

Identification of Genetic Causes of Bicuspid Aortic Valve Disease

Condition:   Bicuspid Aortic Valve
Intervention:  
Sponsors:   Beth Israel Deaconess Medical Center;   Massachusetts General Hospital;   Brigham and Women's Hospital
Recruiting

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