Precision Health Clinical Trials

Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients

Condition:   Solid, Liquid, Central Nervous System Tumors
Interventions:   Other: Study Introduction Visit;   Other: Informed Consent Visit;   Other: Informed Consent Follow-Up Visit;   Other: Return of Results Conversation;   Other: Return of Results Follow-Up Visits;   Procedure: Blood Sample;   Procedure: Skin Biopsy
Sponsor:   St. Jude Children's Research Hospital

Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases

Conditions:   Spinal Muscular Atrophy;   Charcot-Marie-Tooth Disease;   Muscular Dystrophy;   Spinal Muscular Atrophy With Respiratory Distress 1;   Amyotrophic Lateral Sclerosis;   Motor Neuron Disease;   Neuromuscular Disease;   Peroneal Muscular Atrophy
Intervention:   Other: sample collection
Sponsor:   Nemours Children's Clinic

Autologous Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy and Adrenoleukodystrophy

Conditions:   Metachromatic Leukodystrophy;   Adrenoleukodystrophy
Intervention:   Genetic: transduced CD34+ hematopoietic stem cell
Sponsors:   Shenzhen Second People's Hospital;   Shenzhen University;   Guangzhou Women and Children's Medical Center

Whole Genome Sequencing for Blood Group Genotyping and Definition as Exemplified on U- and St(a)+.

Condition:   Genetic Blood Group (bg) Polymorphism in U Negativity and St(a) of MNSs
Intervention:   Other: Whole Genome Sequencing (WGS)
Sponsor:   Blood Donation Service Zurich, SRC

To Study The Influence Of Genomic Factors On Metabolism And Effects Of Clomiphene In Asian Normogonadotrophic Anovulatory Patients.

Condition:   Infertility, Female
Sponsors:   KK Women's and Children's Hospital;   National Cancer Centre, Singapore

Genetic Variants of Selected Genes in Colo-Rectal Cancer Patients.

Condition:   Cancer Colon
Intervention:   Genetic: Whole genome sequencing
Sponsors:   Sherief Abd-Elsalam;   Tanta University

Minimal Residual Disease as a Possible Predictive Factor for Relapse in Patients With AL Amyloidosis

Conditions:   Amyloidosis;   Primary Amyloidosis
Sponsor:   Tufts Medical Center

Identification of a Biomarker Associated With Cis-duplication of the SMN1 Gene

Condition:   Spinal Muscular Atrophy
Intervention:   Procedure: blood sampling
Sponsors:   University Hospital, Rouen;   Society GENOMIC VISION

Protocols Development for Single Cells Genomics and Their Implementation for Molecular Diversity Between Cells

Condition:   Healthy
Intervention:   Other: non
Sponsor:   Hadassah Medical Organization
Not yet recruiting

Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma

Conditions:   Carcinoma, Squamous Cell;   Carcinoma, Squamous;   Squamous Cell Carcinoma;   Lung Neoplasms;   Cancer of Lung;   Cancer of the Lung;   Lung Cancer;   Neoplasms, Lung;   Neoplasms, Pulmonary;   Pulmonary Cancer;   Pulmonary Neoplasms
Intervention:   Genetic: DNA Extraction
Sponsor:   Mayo Clinic