Precision Health Clinical Trials

Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations

Conditions:   Advanced Ovarian Cancer;   Primary Peritoneal Cancer;   Advanced Breast Cancer;   Advanced Solid Tumors
Intervention:   Drug: BMN 673
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their Patents

Conditions:   Fanconi Anemia;   Autosomal or Sex Linked Recessive Genetic Disease;   Bone Marrow Hematopoiesis Failure, Multiple Congenital Abnormalities, and Susceptibility to Neoplastic Diseases.;   Hematopoiesis Maintainance.
Interventions:   Genetic: human whole exome;   Genetic: whole genomic
Sponsor:   Xiaofan Zhu
Available

For more information, visit the Study URL.

Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use

Conditions:   Osteoporosis, With or Without Treatment;   Bisphosphonate Treatment;   Atypical Femur Fracture;   Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ);   Healthy Volunteers
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting

For more information, visit the Study URL.

The Impact of Placental Factors on Fetal Intrauterine Growth and in Intrauterine Programming of the Metabolic Syndrome

Condition:   Normal Pregnancies
Intervention:  
Sponsor:   Meir Medical Center
Not yet recruiting

For more information, visit the Study URL.

Genetic Risks for Bicuspid Aortic Valve Disease

Conditions:   Bicuspid Aortic Valve;   Unicuspid Aortic Valve
Intervention:  
Sponsor:   The University of Texas Health Science Center, Houston
Recruiting

For more information, visit the Study URL.

Genomic Profiling in Cancer Patients

Conditions:   Solid Tumors;   Hematologic Cancers
Interventions:   Genetic: molecular profiling of tumors;   Genetic: Clinical Germline Analysis
Sponsor:   Memorial Sloan Kettering Cancer Center
Recruiting

For more information, visit the Study URL.

AZD1775 for Advanced Solid Tumors

Conditions:   Neoplasms;   Lymphoma
Intervention:   Drug: MK-1775 (AZD1775)
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

Biomarkers in Predicting Treatment Response in Samples From Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant Chemotherapy

Conditions:   Stage IA Non-small Cell Lung Cancer;   Stage IB Non-small Cell Lung Cancer;   Stage IIA Non-small Cell Lung Cancer;   Stage IIB Non-small Cell Lung Cancer;   Stage IIIA Non-small Cell Lung Cancer
Interventions:   Other: medical chart review;   Other: laboratory biomarker analysis
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

For more information, visit the Study URL.

Identification of Genetic Causes of Bicuspid Aortic Valve Disease

Condition:   Bicuspid Aortic Valve
Intervention:  
Sponsors:   Beth Israel Deaconess Medical Center;   Massachusetts General Hospital;   Brigham and Women's Hospital
Recruiting

For more information, visit the Study URL.

The Healthy Elderly Longevity Cohort

Condition:   Healthy
Intervention:  
Sponsor:   Scripps Translational Science Institute
Recruiting

For more information, visit the Study URL.

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