Precision Health Clinical Trials

Acute Kidney Injury Genomics and Biomarkers in TAVR Study

Conditions:   Acute Kidney Injury;   Renal Insufficiency, Chronic;   Heart Failure;   Myocardial Infarction;   Arrhythmias, Cardiac;   Stroke
Intervention:   Procedure: Transcatheter Aortic Valve Replacement
Sponsor:   University of Texas Southwestern Medical Center

Genomic Translation for Amyotrophic Lateral Sclerosis Care

Condition:   ALS
Sponsors:   Columbia University;   ALS Association;   Biogen

Follow-up of a National Cohort of Melanoma Stage IV and Unresectable Stage III Patients

Condition:   Malignant Melanoma
Interventions:   Other: Biological;   Other: Tissular;   Other: Quality of life
Sponsors:   Assistance Publique - Hôpitaux de Paris;   National Cancer Institute (NCI)

Clinical and Genetic Study of Familial Sarcoidosis (SARCFAM)

Condition:   Sarcoidosis
Intervention:   Genetic: Genetic analysis by SANGER and WHOLE EXOME NEXT GENERATION SEQUENCING
Sponsor:   Hospices Civils de Lyon

Evaluation Interest of the Circulating Tumor DNA Dosage in Patient With Hepatic Metastatic Uveal Melanoma Candidate to Complete Resection (ct DNA R0)

Condition:   Uveal Melanoma
Intervention:   Biological: Blood sampling
Sponsor:   Institut Curie

Natural History of and Specimen Banking for People With Tumors of the Central Nervous System

Conditions:   Brain Cancer;   Brain Tumor;   Spine Cancer;   Spine Tumor;   Neoplasm
Sponsor:   National Cancer Institute (NCI)

Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

Conditions:   Breast Cancer;   Lung Cancer;   Colorectal Cancer;   Melanoma;   Gynecological Cancer;   Genitourinary Cancer;   Pancreatobiliary Cancer;   Gastrointestinal Cancer;   Head and Neck Cancer;   Rare Cancer;   Unknown Primary Cancer
Sponsors:   University Health Network, Toronto;   Princess Margaret Hospital, Canada

Vaginal and Urinary Microbiome Trial

Conditions:   Atrophic Vaginitis;   Menopause;   Recurrent Urinary Tract Infections
Interventions:   Drug: Premarin vaginal cream;   Drug: Apricot kernel oil
Sponsor:   University of Louisville

Identification of Epigenetic Markers Common to Obesity and Alzheimer's Disease in Women

Conditions:   Obesity;   Alzheimer's Disease
Intervention:   Procedure: Blood sample
Sponsor:   Central Hospital, Nancy, France
Not yet recruiting

The Drug Rediscovery Protocol (DRUP Trial)

Conditions:   Cancer;   Tumors;   Neoplasm;   Neoplasia
Interventions:   Drug: Panitumumab;   Drug: Olaparib;   Drug: Dabrafenib;   Drug: Nilotinib;   Drug: Trametinib;   Drug: Erlotinib;   Drug: Trastuzumab and Pertuzumab (combination treatment);   Drug: Vemurafenib and Cobimetinib (combination treatment);   Drug: Vismodegib;   Drug: Regorafenib;   Drug: Nivolumab;   Drug: Afatinib;   Drug: Dabrafenib and trametinib;   Drug: Ribociclib;   Drug: Lenvatinib;   Drug: Pembrolizumab;   Drug: Durvalumab;   Drug: Rucaparib;   Drug: Axitinib;   Drug: Palbociclib;   Drug: Crizotinib;   Drug: Sunitinib;   Drug: Cabozantinib;   Drug: Abemaciclib;   Drug: Alectinib;   Drug: Atezolizumab and Bevacizumab;   Drug: Ipilimumab and nivolumab;   Drug: Entrectinib;   Drug: Talazoparib;   Drug: Dacomitinib;   Drug: Lorlatinib;   Drug: Erdafitinib;   Drug: Alpelisib
Sponsors:   The Netherlands Cancer Institute;   Amgen;   AstraZeneca;   Bayer;   Bristol-Myers Squibb;   Novartis;   Roche Pharma AG;   Merck Sharp & Dohme LLC;   Boehringer Ingelheim;   Ipsen;   Eisai Inc.;   Pfizer;   Clovis Oncology, Inc.;   Eli Lilly and Company;   Janssen, LP