Precision Health Clinical Trials

Contribution of High Throughput RNA Sequencing Combined With Sequencing of Whole Genomes in the Diagnosis of Intellectual Disability

Conditions:   Patients With Intellectual Disabilities Without an Obvious Clinical Diagnosis;   Patients With Normal Array CGH and Previous Negative Genetic Investigations (WES-solo or WES-trio)
Interventions:   Biological: Patient blood sampling;   Biological: Parents blood sampling
Sponsor:   Centre Hospitalier Universitaire Dijon
Recruiting

For more information, visit the Study URL.

Integrative Sequencing In Germline and Hereditary Tumours

Conditions:   Hereditary Cancer Syndrome;   High-Risk;   Mutation;   Germline Mutation
Intervention:  
Sponsor:   University Health Network, Toronto
Recruiting

For more information, visit the Study URL.

Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors

Conditions:   Mismatch Repair Proficient Colorectal Cancer;   Pancreatic Adenocarcinoma;   Leiomyosarcoma
Interventions:   Biological: Durvalumab;   Drug: Olaparib;   Drug: Cediranib
Sponsors:   University Health Network, Toronto;   AstraZeneca
Recruiting

For more information, visit the Study URL.

South-seq: Deoxyribonucleic Acid (DNA) Sequencing for Newborn Nurseries in the South

Condition:   Whole Genome Sequencing
Interventions:   Behavioral: Genetic Counselor;   Behavioral: Trained Healthcare Provider
Sponsors:   University of Alabama at Birmingham;   University of Mississippi Medical Center;   HudsonAlpha Institute for Biotechnology;   Woman's Hospital, Louisiana;   Children's Hospital of New Orleans;   Norton's Children's Hospital;   University of Louisville
Recruiting

For more information, visit the Study URL.

Genomic and Phenotypic Determinants of Resistance to Immunotherapies in Multiple Myeloma

Condition:   Multiple Myeloma
Intervention:   Diagnostic Test: Evaluation of patients resistance to immunotherapies in Multiple Myeloma
Sponsor:   University of Turin, Italy
Recruiting

For more information, visit the Study URL.

The Tracking Molecular Evolution for NSCLC (T-MENC) Study

Conditions:   Lung Neoplasms;   Lung Cancer;   Nonsmall Cell Lung Cancer;   Adenocarcinoma of Lung
Intervention:  
Sponsors:   Geneplus-Beijing Co. Ltd.;   Xuanwu Hospital, Beijing
Recruiting

For more information, visit the Study URL.

The Relationship Between ALDH2 and Aortic Dissection

Condition:   Aortic Dissection
Intervention:  
Sponsor:   Qilu Hospital of Shandong University
Recruiting

For more information, visit the Study URL.

Pediatric Reporting of Adult-Onset Genomic Results

Conditions:   Hereditary Breast and Ovarian Cancer Syndrome;   Lynch Syndrome;   Familial Hypercholesterolemia
Interventions:   Genetic: Receive an adult-onset result;   Genetic: Receive a pediatric-onset result;   Genetic: Control - No Result
Sponsors:   Geisinger Clinic;   National Human Genome Research Institute (NHGRI)
Recruiting

For more information, visit the Study URL.

Clinical, Psychological and Genetic Characteristics in Dermatological Patients

Conditions:   Atopic Dermatitis;   Psoriasis
Intervention:  
Sponsors:   Astana Medical University;   Ariel University;   Tirat Carmel Mental Health Center;   Medical Centre Hospital of the President’s Affairs Administration, Republic of Kazakhstan
Recruiting

For more information, visit the Study URL.

The TOGETHER Project - Heart

Condition:   Heart Transplant Rejection
Intervention:  
Sponsor:   Mayo Clinic
Recruiting

For more information, visit the Study URL.

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