Precision Health Clinical Trials

Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors

Conditions:   Mismatch Repair Proficient Colorectal Cancer;   Pancreatic Adenocarcinoma;   Leiomyosarcoma
Interventions:   Biological: Durvalumab;   Drug: Olaparib;   Drug: Cediranib
Sponsors:   University Health Network, Toronto;   AstraZeneca
Recruiting

For more information, visit the Study URL.

Integrative Sequencing In Germline and Hereditary Tumours

Conditions:   Hereditary Cancer Syndrome;   High-Risk;   Mutation;   Germline Mutation
Intervention:  
Sponsor:   University Health Network, Toronto
Recruiting

For more information, visit the Study URL.

Contribution of High Throughput RNA Sequencing Combined With Sequencing of Whole Genomes in the Diagnosis of Intellectual Disability

Conditions:   Patients With Intellectual Disabilities Without an Obvious Clinical Diagnosis;   Patients With Normal Array CGH and Previous Negative Genetic Investigations (WES-solo or WES-trio)
Interventions:   Biological: Patient blood sampling;   Biological: Parents blood sampling
Sponsor:   Centre Hospitalier Universitaire Dijon
Recruiting

For more information, visit the Study URL.

South-seq: Deoxyribonucleic Acid (DNA) Sequencing for Newborn Nurseries in the South

Condition:   Whole Genome Sequencing
Interventions:   Behavioral: Genetic Counselor;   Behavioral: Trained Healthcare Provider
Sponsors:   University of Alabama at Birmingham;   University of Mississippi Medical Center;   HudsonAlpha Institute for Biotechnology;   Woman's Hospital, Louisiana;   Children's Hospital of New Orleans;   Norton's Children's Hospital;   University of Louisville
Recruiting

For more information, visit the Study URL.

Genomic and Phenotypic Determinants of Resistance to Immunotherapies in Multiple Myeloma

Condition:   Multiple Myeloma
Intervention:   Diagnostic Test: Evaluation of patients resistance to immunotherapies in Multiple Myeloma
Sponsor:   University of Turin, Italy
Recruiting

For more information, visit the Study URL.

The Tracking Molecular Evolution for NSCLC (T-MENC) Study

Conditions:   Lung Neoplasms;   Lung Cancer;   Nonsmall Cell Lung Cancer;   Adenocarcinoma of Lung
Intervention:  
Sponsors:   Geneplus-Beijing Co. Ltd.;   Xuanwu Hospital, Beijing
Recruiting

For more information, visit the Study URL.

Diagnosis of Colorectal Cancer and Advanced Adenoma Using Cancer-specific Methylation Signatures

Conditions:   Colorectal Cancer;   Advanced Adenoma
Intervention:  
Sponsors:   Shanghai Zhongshan Hospital;   West China Hospital;   Guangzhou First People's Hospital;   Dalian University Affiliated Xinhua Hospital;   Fudan University;   Singlera Genomics Inc.
Recruiting

For more information, visit the Study URL.

Study of Pembrolizumab or Placebo Following Surgery in Patients With Microsatellite Instability High (MSI-H) Solid Tumors

Conditions:   Solid Tumors;   Identified by NGS, PCR or IHC
Interventions:   Drug: Pembrolizumab;   Drug: Placebo
Sponsors:   Memorial Sloan Kettering Cancer Center;   Merck Sharp & Dohme Corp.
Recruiting

For more information, visit the Study URL.

The TOGETHER Project - Heart

Condition:   Heart Transplant Rejection
Intervention:  
Sponsor:   Mayo Clinic
Recruiting

For more information, visit the Study URL.

Clinical, Psychological and Genetic Characteristics in Dermatological Patients

Conditions:   Atopic Dermatitis;   Psoriasis
Intervention:  
Sponsors:   Astana Medical University;   Ariel University;   Tirat Carmel Mental Health Center;   Medical Centre Hospital of the President’s Affairs Administration, Republic of Kazakhstan
Recruiting

For more information, visit the Study URL.

Pages