Precision Health Clinical Trials

Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics

Conditions:   Biliary Tract Neoplasms;   Gastric Cancer;   Esophageal Squamous Cell Carcinoma;   Colorectal Cancer;   Gastrointestinal Stromal Tumors;   Pancreatic Cancer;   Neuroendocrine Tumors;   Unknown Primary Cancer;   Digestive Cancer
Interventions:   Drug: FGFR Inhibitor, IDH1 Inhibitor, HER2 Inhibitor, PARP Inhibitor, BRAF Inhibitor, MEK Inhibitor, ICIs, EGFR-TKIs, NTRK-TKI, and et. al.;   Drug: Other Therapy
Sponsors:   Peking University;   Hangzhou DIAN Medical Diagnostic Center Co., Ltd., China
Recruiting

For more information, visit the Study URL.

Transcriptional and Immine Parameters of Response to Belinumab

Condition:   Systemic Lupus Erythematosus
Intervention:   Drug: Belimumab
Sponsor:   Biomedical Research Foundation, Academy of Athens
Not yet recruiting

For more information, visit the Study URL.

Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer

Conditions:   Biliary Tract Cancer;   Cholangiocarcinoma;   Gallbladder Cancer;   Intrahepatic Cholangiocarcinoma;   Perihilar Cholangiocarcinoma;   Extrahepatic Cholangiocarcinoma;   Hilar Cholangiocarcinoma;   Distal Bile Duct Cancer
Intervention:   Diagnostic Test: Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring
Sponsors:   University of Washington;   Natera, Inc.;   SEngine Precision Medicine, Inc.
Recruiting

For more information, visit the Study URL.

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

Conditions:   Oropharyngeal Squamous Cell Carcinoma;   Carcinoma, Squamous Cell;   Head and Neck Squamous Cell Carcinoma;   Oropharynx Squamous Cell Carcinoma
Intervention:  
Sponsors:   UNC Lineberger Comprehensive Cancer Center;   Mayo Clinic
Recruiting

For more information, visit the Study URL.

Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools

Condition:   Developmental Disorders
Interventions:   Genetic: genome-wide analyses;   Genetic: Search for de novo mutations in paternal sperm samples
Sponsor:   University Hospital, Rouen
Not yet recruiting

For more information, visit the Study URL.

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

Conditions:   Advanced Pancreatic Carcinoma;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IV Breast Cancer AJCC v8;   Castration-Resistant Prostate Carcinoma;   Clinical Stage III Gastric Cancer AJCC v8;   Clinical Stage IV Gastric Cancer AJCC v8;   HER2-Positive Breast Carcinoma;   Locally Advanced Breast Carcinoma;   Locally Advanced Gastric Carcinoma;   Locally Advanced Malignant Solid Neoplasm;   Locally Advanced Ovarian Carcinoma;   Locally Advanced Pancreatic Carcinoma;   Locally Advanced Prostate Carcinoma;   Metastatic Breast Carcinoma;   Metastatic Gastric Carcinoma;   Metastatic Malignant Solid Neoplasm;   Metastatic Ovarian Carcinoma;   Metastatic Pancreatic Carcinoma;   Metastatic Prostate Carcinoma;   Platinum-Sensitive Ovarian Carcinoma;   Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8;   Stage II Pancreatic Cancer AJCC v8;   Stage III Ovarian Cancer AJCC v8;   Stage III Pancreatic Cancer AJCC v8;   Stage III Prostate Cancer AJCC v8;   Stage IV Ovarian Cancer AJCC v8;   Stage IV Pancreatic Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8
Interventions:   Procedure: Biopsy;   Procedure: Biospecimen Collection;   Procedure: Computed Tomography;   Procedure: Magnetic Resonance Imaging;   Drug: Talazoparib
Sponsor:   National Cancer Institute (NCI)
Recruiting

For more information, visit the Study URL.

ANXA5 M2 Haplotyping in IVF Patients and Embryos

Conditions:   Infertility;   Miscarriage, Recurrent;   Pregnancy Complications
Intervention:   Other: M2 Test
Sponsor:   Genomic Prediction Inc.
Recruiting

For more information, visit the Study URL.

Sub-study of the Essen Study Centre for the ENTAiER Trial

Conditions:   Elderly Patients;   Chronically Ill;   Increased Risk of Falling
Interventions:   Other: Eurythmy Therapy;   Other: Tai Chi;   Other: Standard Care
Sponsors:   Universität Duisburg-Essen;   Software AG Stiftung;   Universität Freiburg
Not yet recruiting

For more information, visit the Study URL.

Integrative Proteomic Characterization of Pancreatic Ductal Adenocarcinoma

Condition:   Tumor Tissues and Non-tumor Tissues From PDAC Patients Were Used for Genomic and Transcriptome Sequencing Analysis and Proteomics and Phosphorylated Proteomics
Intervention:   Other: No intervention
Sponsor:   Ruijin Hospital
Not yet recruiting

For more information, visit the Study URL.

Embryo Health Study

Conditions:   Infertility;   Hereditary Diseases
Intervention:   Other: Preimplantation Genetic Testing
Sponsor:   Genomic Prediction Inc.
Recruiting

For more information, visit the Study URL.

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