Precision Health Clinical Trials

Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer

Conditions:   Recurrent Non-small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
Interventions:   Other: cytology specimen collection procedure;   Other: laboratory biomarker analysis
Sponsors:   Barbara Ann Karmanos Cancer Institute;   National Cancer Institute (NCI)

Establishment of NAFLD Cohort and Development of Fibrosis Markers

Condition:   Fibrosis of Liver
Interventions:   Procedure: Liver biopsy;   Device: ARFI;   Device: SWE;   Device: Transient elastography
Sponsor:   Seoul National University Boramae Hospital

Molecular-Guided Therapy for Childhood Cancer

Conditions:   Neuroblastoma;   Medulloblastoma;   Glioma;   Ependymoma;   Choroid Plexus Neoplasms;   Craniopharyngioma;   Dysembryoplastic Neuroepithelial Tumor;   Meningioma;   Primitive Neuroectodermal Tumors (PNETs);   Germ Cell Tumors;   Rhabdomyosarcoma;   Non-rhabdomyosarcoma;   Ewings Sarcoma;   Osteosarcoma;   Wilms Tumor;   Renal Cell Carcinoma;   Malignant Rhabdoid Tumor;   Clear Cell Sarcoma;   Liver Tumors
Intervention:   Device: Guided Therapy
Sponsors:   Giselle Sholler;   Translational Genomics Research Institute;   Dell, Inc.

Next Generation pErsonalized tX(Therapy) With Plasma DNA Trial-2 in Refractory Solid Tumors (The NEXT-2 Trial)

Conditions:   Metastatic Gastrointestinal Cancer;   Genitourinary Cancer
Sponsor:   Samsung Medical Center

Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases

Condition:   Retinitis Pigmentosa
Intervention:   Genetic: Genetic testing
Sponsors:   Hillel Yaffe Medical Center;   Technion, Israel Institute of Technology
Not yet recruiting

Using Microbial Genomics to Elucidate the Source of Central-line Associated Bloodstream Infections

Conditions:   Laboratory-confirmed Bloodstream Infection;   Central Line-associated Bloodstream Infections;   Mucosal Barrier Injury
Sponsor:   Boston Children's Hospital

Comprehensive Genomic Analysis in Tissue and Blood Samples From Young Patients With Lung Cancer

Conditions:   Non-small Cell Lung Cancer;   Small Cell Lung Cancer
Interventions:   Other: cytology specimen collection procedure;   Other: laboratory biomarker analysis
Sponsors:   University of Southern California;   Foundation Medicine;   Addario Lung Cancer Medical Institute;   National Cancer Institute (NCI)

Analysis of Human Genomic DNA in Embryo's Culture Media

Condition:   Single-Gene Disease
Intervention:   Genetic: Polymerase Chain Reaction and Whole Genome Amplification
Sponsor:   Cervesi Hospital, Cattolica, Italy

A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics

Conditions:   Atrial Fibrillation;   Deep Vein Thrombosis;   Cardiac Valvular Insufficiency;   Coagulopathies;   Pulmonary Embolism
Interventions:   Genetic: Genotype-guided;   Other: Standard-of-Care
Sponsors:   University of Puerto Rico;   National Institute on Minority Health and Health Disparities (NIMHD);   Genomas, Inc

Capturing BRCA1/2 Mutational Status in Women With High Grade Serous Ovarian Cancer and Impact on Clinical Outcome.

Condition:   Ovarian Cancer
Intervention:   Genetic: BRCA genetic data
Sponsor:   University Health Network, Toronto