Official Title
Comprehensive Precision Oncology Program at The Chinese University of Hong Kong
Brief Title
PRecision Oncology CUhk pRogrammE (PRO-CURE)
Protocol ID
NCT04724070
Lead Sponsor
Brigette Ma
Brief Summary
The main aim of this project is to establish an innovative model of a comprehensive
precision oncology platform to help individualizing drug therapy for patients with
advanced cancers at The Chinese University of Hong Kong. The other objectives include to
optimize the genomic matching and access of patients with unique cancer subtypes to the
relevant clinical trials of novel therapies, and to construct a personalized drug
screening platform for individuals using novel cancer models established from
patient-derived cancer cells and tissues. Other objectives include to investigate the
utility and feasibility of genomic sequencing using circulating tumor DNA(ctDNA), and to
establish a biobank of tumor tissues derived from patients with unique cancer subtypes.
Study Period
-
Enrollment Count
200 participants
Eligibility Criteria
Inclusion Criteria:
- Must be aged between 18 to 75 years
- Must have ECOG performance status of 0 to 1
- Must have histologically/cytologically confirmed cancers of certain subtype
- Medically fit patients who would need systemic therapy as part of their oncological
treatment in any one or more of the following oncological setting(s): palliative,
neoadjuvant, adjuvant, concurrent with radiotherapy. This includes patients who have
limited systemic therapeutic options for their cancers and are candidates for
clinical trials.
- Able to give written informed consent
- Willing to have blood samples taken.
- Availability of an archived paraffin-embedded tumor block
Exclusion Criteria:
- Patients who refuse or are medically unfit for systemic therapy for their cancer
- Patients with more than one invasive cancers diagnosed over the last FIVE years.
- Patients without measurable tumor lesions on radiological imaging
- Patients who are unable to give written informed consent.
Filters
Gastrointestinal Cancers
RECRUITING
ADULT
OLDER_ADULT