Official Title
Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research
Brief Title
KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis
Protocol ID
NCT03929887
Lead Sponsor
Seoul National University Hospital
Brief Summary
Glomerulonephritis (GN) generates an enormous individual and social economic burden.
However, the therapeutic options are largely based on clinical and pathological
parameters and the individual response to therapy or prognosis is uncertain.
Recently, along with advances in molecular analysis and computational bioinformatics,
genomic data from human renal biopsies could provide a strong foundation for the future
of precision medicine in nephrology.
In response to a request for applications by the Ministry of Health and Welfare of Korea
for the creation of Clinical Research Registry, multi-center N network has been
established for prospective cohort with kidney biopsy samples (KORNERSTONE).
Through this Network the investigators hope to understand the fundamental biology of
glomerulonephritis and aim to bank long-term observational data and corresponding
biological data including genomic data from kidney tissues, and kidney pathologic data
which is digitalized This database is archived to a web-based platform to access easily
and further enrich for researchers.
Detailed Description
Glomerulonephritis (GN) such as Minimal change disease (MCD), focal segmental
glomerulosclerosis (FSGS), Membranous nephropathy (MN), and Immunoglobulin A nephropathy
(IgAN) has quite a common clinical presentation often results in renal insufficiency
which generates an enormous individual and social economic burden.
However, the therapeutic options are largely based on clinical and pathological
parameters and the individual response to therapy or prognosis is uncertain.
Recently, along with advances in molecular analysis and computational bioinformatics,
genomic data from human renal biopsies could provide a strong foundation for the future
of precision medicine in nephrology.
In response to a request for applications by the Ministry of Health and Welfare of Korea
for the creation of Clinical Research Registry, a number of universities joined together
to establish Korean Kidney Biopsy Network (KORNERSTONE).
Through this Network the investigators hope to understand the fundamental biology of
glomerulonephritis and aim to bank long-term observational data and corresponding
biological data including genomic data from kidney tissues, and kidney pathologic data
which is digitalized This database is archived to a web-based platform to access easily
and further enrich for researchers.
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1. Blood tests: CBC, Chemistry (Ca, P, Glucose, Total protein, Albumin, Uric acid),
Electrolyte, Renal function (BUN, Creatinine, eGFR), Liver function (AST, ALT)
2. Immunologic blood tests: Complement 3, Complement 4, ASO, RF, Cryoglobulin, dsDNA,
ANA
3. Urine tests: Urinalysis, Urine protein, Urine albumin, Urine creatinine
4. Radiologic tests: Kidney USG, Abdominal-pelvis computed tomography
5. Pathologic results
6. Treatment informations: treatment status, drug type, treatment duration
7. Quality of life questionnaire: Kidney Disease and Quality of Life Short Form survey
(adults), PedsQL 4.0 Generic Core Scales (pediatrics)
8. Dietary questionnaire
Study Period
-
Enrollment Count
3,000 participants
Eligibility Criteria
1. Inclusion criteria
- Patient suspected of glomerular disease who received kidney biopsy in
participating university medical centers
- Children (age<18 years) also included
2. Exclusion criteria - Patients who previously received a kidney transplant
Filters
Glomerular Disease
Minimal Change Disease
IgA Nephropathy
Membranous Nephropathy
Focal Segmental Glomerulosclerosis
Lupus Nephritis
Crescentic Glomerulonephritis
RECRUITING
CHILD
ADULT
OLDER_ADULT