NCT03919110 - Immunome Project Consortium for Autoinflammatory Disorders

Inclusion Criteria for guSAID Patients - SAID patients with an as yet unidentified genetic cause. - Patients diagnosed according to the specific diagnostic criteria of each diseases. For each - subgroup, the diagnosis will be based on accepted criteria. - Patients with active disease (presence of a flare) according to the specific criteria for each disease (Cf. Table 2) - For age criteria, please refer to each subgroup - Patients covered by a health insurance - Signature of the informed consent (parents/legal representative if the patient is less than <18 years old) Exclusion Criteria for guSAID Patients: - Active chronic infection included chronic viral infection (HIV, HBV, HCV…) - Recent infection or antibiotic treatment in the last 2 weeks - Systemic auto-immune disease - Other etiology of fever (infection or neoplasia) - Monogenic auto-inflammatory disease (other than FMF, HIDS, TRAPS, CAPS) - Genetic macrophage activation syndrome - Evidence of immuno-deficiency (e.g., transplant recipient, immunosuppressive treatment for other conditions etc.) - Pregnancy - Individuals deprived of liberty - Inability to understand the local language - Protected persons (under guardianship or curatorship) Inclusion criteria for parents of guSAID patients - First-degree biological relationship (no adoption) with the index patient - Mother and Father aged more than 18 years old - Health insurance coverage - Signature of the informed consent form Exclusion criteria for parents of guSAID patients - Any condition which in the Investigator's opinion makes it undesirable for the subject to - - participate in the study or which would jeopardize compliance with the protocol - Individuals deprived of liberty - Inability to understand the local language - Protected persons Inclusion criteria for mSAID patients - Patients with monogenic hereditary SAID - Patients diagnosed according to the specific diagnostic criteria of each diseases. EUROFEVER criteria for clinical definition plus genetic criterion - Patients with active disease (presence of a flare and/ or persistent chronic inflammation) : - Patients older than 6 months can be recruited - Patients with health insurance - Signature of the informed consent form Exclusion criteria for mSAID Patients - Active chronic infection included chronic viral infection (HIV, HBV, HCV…) - Recent infection or antibiotic treatment - Systemic auto-immune disease - Other etiology of fever (infection or neoplasia) - Monogenic auto-inflammatory disease (other than FMF, HIDS, TRAPS, CAPS) - Genetic macrophage activation syndrome - Evidence of immuno-deficiency - Pregnancy - Individuals deprived of liberty - Inability to understand the local language - Protected persons Inclusion criteria for negative control - Subject free of inflammatory disorders and negative CRP at enrollment - Subject without personal or familial history of SAID - Subject aged from 10 to 60 years old - Subject with health insurance - Signature of the informed consent form Exclusion criteria for negative control - Active bacterial, viral, fungal, or opportunistic infections - Recent infection or antibiotic treatment in the last 2 weeks - History of any inflammatory, auto-inflammatory or auto-immune disease - History of systemic corticosteroid or non-steroidal (NSAID) therapy within the last 4 weeks - History of neoplasia with the exception of adequately treated basal and squamous cell - - carcinoma of the skin, or carcinoma in situ of the cervix - Evidence of immunocompromised - End stage renal disease (eGFR <20 mL/min/1.73m2) - Comorbidities requiring corticosteroid therapy, including those which have required three or more courses of systemic corticosteroids within the previous 12 months - Pregnancy - Current substance abuse or history of substance abuse within the past year. - Lack of peripheral venous access - Individuals deprived of liberty - Inability to understand the local language - Protected persons (under guardianship or curatorship)