NCT02481336 - To Study the Individual Variants of Chemotherapy-Induced Neurotoxicity

Inclusion Criteria: 1. Histologically confirmed epithelial ovarian cancer, endometrial cancer or adenocarcinoma of colon or rectum 2. Pathological stage I~IV for ovarian cancer, stage II~IV endometrial cancer or stage III & high risk stage II for colorectal cancer 3. Scheduled to receive adjuvant Paclitaxel/Carboplatin for ovarian or endometrial cancer, or mFOLFOX6 for colorectal cancer 4. Age ≥ 20 years old 5. ECOG Performance status 0-1 6. Adequate organ function Bone marrow: Absolute neutrophil count (ANC) ≥ 1.5 x 109/L WBC ≥ 3.0 x 109/L Platelet count ≥ 100 x 109/L Hemoglobin ≥ 9 g/dL Hepatic: Total bilirubin level ≤ 1.0 x UNL AST and ALT ≤ 3.0 x UNL Renal: Creatinine level ≤ 1.5 mg/dL in men, ≤1.4 mg/dL in women; or Estimated CCr ≥ 60 mL/min (CCr is estimated by Cockcroft-Gault formula, as appendix III). 7. Negative pregnancy test for women of childbearing potential only 8. Patient willing to provide blood sample for research purposes 9. Written informed consent Exclusion Criteria: 1. Prior treatment with neurotoxic chemotherapy, such as oxaliplatin, cisplatin, carboplatin, taxanes or vinca alkaloids 2. Receiving chemotherapy within 6 months 3. History of allergy to 5-FU or LV 4. Pre-existing peripheral neuropathy of any grade 5. A family history of a genetic or familial neuropathy 6. Active uncontrolled infection 7. Significant medical diseases, such as unstable angina, acute or recent myocardial infarction (<6 months before enrollment), COPD with frequent exacerbation, uncontrolled hypertension, ore cent CVA (<6 months before enrollment) 8. Poor compliance