Official Title
Study of Leukocyte Populations in Patients With Chronic Inflammatory
Brief Title
Study of Leukocyte Populations in Patients With Chronic Inflammatory
Protocol ID
NCT04749875
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Brief Summary
Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare
systemic autoimmune diseases with the objective of identifying therapeutic targets.
Detailed Description
The primary objective is to characterization of the quantitative and qualitative
specificities of the different leukocyte sub-populations in patients with chronic
inflammatory rheumatism and rare systemic autoimmune diseases. We will perform an
exploratory descriptive study whom primary endpoint will be to assess by FACS the
phenotype of the specific leukocyte subsets. In addition, we will characterize the
protein and transcriptomic signature associated with the conditions for which we have
obtained preliminary data showing their potential involvement in autoimmunity (i.e: IL7
pathway, IFN signature).
Study Period
-
Enrollment Count
1,500 participants
Eligibility Criteria
Inclusion Criteria:
- Age ≥18 years
- Patient who did not express his opposition
- Patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases
(pSS, lupus, scleroderma, myositis, unclassified connectivitis) diagnosed according
to the usual criteria.
- Weight> 35 kg
Exclusion Criteria:
- Corticosteroid treatment> 10 mg / day
- Pregnant patient
- Patients under legal protection
- Beneficiary of the state medical aid
Filters
Systemic Autoimmune Disease
Chronic Inflammatory Rheumatism
Sjogren's Syndrome
Spondyloarthritis
Rheumatoid Arthritis
Systemic Lupus Erythematosus
UNKNOWN
ADULT
OLDER_ADULT