Official Title
Extreme Lipids Repository
Brief Title
Extreme Lipids Repository
Protocol ID
NCT04156997
Lead Sponsor
University of Texas Southwestern Medical Center
Brief Summary
This is a prospective, observational study to establish a repository of samples from
patients with extreme lipid phenotypes including but not limited to hyperlipidemia,
dyslipidemia, hyperlipoproteinemia, extreme low/high HDL levels and deranged lipoprotein
metabolism. The investigators plan to conduct sophisticated composition and functional
analyses as well as genetic analysis to better understand the determinants of extreme
lipid derangements.
Detailed Description
Participants will be recruited from clinical encounters within the University of Texas
(UT) Southwestern Medical Center and Parkland Hospital by screening the Electronic
Medical Record (EMR) for those with lipid labs and values that satisfy criteria for
extreme values. Identified participants will be recruited to provide health information
via survey, permission to extract clinical information from the EMR, and blood collection
for future analyses. Measurements will span direct measurement of circulating species,
genetic analyses, and analysis of circulating cells. The blood specimens will be stored
for future studies and collaborations and thus, will constitute a blood-based repository.
All study procedures are experimental but do not involve an actual intervention.
Study Period
Enrollment Count
250 participants
Eligibility Criteria
Inclusion Criteria:
- adult patients (age 18 years or older) diagnosed with any lipid or metabolic
disorder including hyperlipidemia, dyslipidemia, hyperlipoproteinemia, low HDL
levels and deranged lipoprotein metabolism
Exclusion Criteria:
- Anyone under 18 years of age will be excluded from the study.
Filters
Lipoprotein Disorder
ACTIVE_NOT_RECRUITING
ADULT
OLDER_ADULT