Official Title
Molecular Predictors of Lung Cancer Behavior
Brief Title
Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer
Protocol ID
NCT00898313
Lead Sponsor
Vanderbilt-Ingram Cancer Center
Brief Summary
RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high
risk of cancer for laboratory studies may help doctors learn more about changes that may
occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at molecular predictors of cancer in patients at
high risk of lung cancer.
Detailed Description
OBJECTIVES:
- To use fixed lung tissue for histological evaluation and fresh tissue samples for
molecular studies to study DNA, RNA, and protein abnormalities in lung preneoplastic
and neoplastic lesions.
- To use proteomic techniques, including matrix-assisted laser desorption
ionization-mass spectrometry (MALDI-MS), to develop a method of diagnosing and
staging both pre-invasive and invasive lesions, using less invasive methods.
OUTLINE: Blood, urine, nasal cell, and sputum samples are collected. Lung tissue samples
are also collected using fluorescence bronchoscopy and epithelial cell collection.
Samples are studied by genetic and proteomic analyses, including comparative genomic
hybridization, expression microarray, and protein profiling.
Enrollment Count
4,000 participants
Eligibility Criteria
Inclusion Criteria:
-All adults referred to Vanderbilt Medical Center, Veterans Administration Medical
Center, St. Thomas Hospital and Meharry Medical Center for evaluation of signs or
symptoms of lung cancer.
Exclusion Criteria:
- Inability to provide informed consent
- Minors
- Pregnant women
Filters
Lung Cancer
UNKNOWN
ADULT
OLDER_ADULT