Official Title
The Impact of Placental Factors on Fetal Intrauterine Growth and in Intrauterine Programming of the Metabolic Syndrome
Brief Title
The Impact of Placental Factors on Fetal Intrauterine Growth and in Intrauterine Programming of the Metabolic Syndrome
Protocol ID
NCT01883154
Lead Sponsor
Meir Medical Center
Brief Summary
Genetic and environmental factors are believed to play a major role in intrauterine
growth and intrauterine programming. We intend to study genetic factors such as Telomere
homeostasis, senescence, genomic instability and the presence of Genomic copy number
variations in placental tissue from pregnancies complicated with Intrauterine growth
restriction(IUGR), Gestational and pre gestational Diabetes, placentas from IVF
pregnancies and from normal pregnancies. We also intend to assess these factors in cord
blood and maternal blood.
Detailed Description
Based on the previous data from our group as well as other laboratories, we postulate
that there is a correlation between impaired telomere homeostasis, senescence genomic
instability and intra-uterine programming in placentas and in fetuses exposed to
suboptimal intrauterine conditions such as hypoxia or hyperglycemia. Improved
understanding of the mechanisms that produce the genomic changes in IUGR placentas and
their influence on later risks of developing the metabolic syndrome should provide basis
for future research that might lead into improved outcome of IUGR fetuses.
Enrollment Count
160 participants
Eligibility Criteria
Inclusion Criteria:
- A diagnosis of Intrauterine growth restriction
- A diagnosis of Gestational diabetes
- A diagnosis of pre gestational Diabetes
- IVF pregnancy
Exclusion Criteria:
- chorioamnionitis
- meconium stained amniotic fluid
- A request of the patient for Cord blood retrieval for preservation
Filters
Normal Pregnancies
UNKNOWN
CHILD
ADULT
OLDER_ADULT