Official Title
iCare for Cancer Patients
Brief Title
iCare for Cancer Patients
Protocol ID
NCT02435550
Lead Sponsor
University of Florida
Brief Summary
The purpose of this study is to use genomic information from individual patients to
create simulation avatars that will be used to predict novel drug combinations with
therapeutic potential.
Detailed Description
As part of normal clinical care, subjects will undergo peripheral blood draws and
biopsies for disease assessment of their cancer. In cases of hematological malignancies,
bone marrow aspiration & biopsy are routinely performed.
As part of this project, the following will be done to the samples collected and with
clinical outcomes data:
- donate peripheral blood specimens whenever blood is already being drawn for clinical
purposes.
- donate bone marrow aspiration samples whenever a bone marrow aspiration procedure is
already being done for clinical purposes.
- donate saliva whenever blood draw is already being done for clinical purposes.
- allow the investigators to perform gene mutation profiling.
- allow the investigators to study gene mutation results.
- allow the investigators to perform pharmacogenetic profiling.
- allow the investigators to study pharmacogenetic profiles.
- allow the investigators to examine chromosome copy number variations.
- allow the investigators to examine genomic methylation.
- allow the investigators to quantify metabolomics/cytokines.
Study Period
-
Enrollment Count
136 participants
Eligibility Criteria
Inclusion Criteria:
- Individuals known or suspected of having a blood cancer or hematologic disorder
- Individuals with presence of extramedullary disease
- Capable of providing informed consent.
Exclusion Criteria:
- Does not have a blood cancer or a hematologic disorder
Filters
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Acute Myelogenous Leukemia
Acute Lymphoid Leukemia
Leukemia, Acute Lymphoblastic
Multiple Myeloma
Myelofibrosis
NA
TERMINATED
ADULT
OLDER_ADULT