Official Title
The Vanderbilt Atrial Fibrillation Ablation Registry
Brief Title
The Vanderbilt Atrial Fibrillation Ablation Registry
Protocol ID
NCT02404415
Lead Sponsor
Vanderbilt University
Brief Summary
The Vanderbilt Atrial Fibrillation Ablation registry (VAFAR) is a prospective clinical
and genetic biorepository that systematically enrolls patients undergoing atrial
fibrillation (AF) ablation. The registry was started in 2011 and has greater than 1000 AF
ablation records with stored blood and DNA samples. The goals of VAFAR are to: 1)
identify clinical, genetic, and serological predictors of response to AF ablation in
order to improve patient selection, and 2) to provide a resource for translational
research investigating the electrophysiologic mechanisms of AF pathogenesis.
Detailed Description
The study population consists of patients at least 18 years of age who are scheduled for
AF ablation at Vanderbilt University. Data recorded at enrollment includes a detailed
past medical history and measurements from pre-ablation imaging (cardiac MRI or CT). At
the time of ablation, a blood sample is collected for storage of plasma/serum and
extraction of DNA, and details of the ablation procedure are recorded. Post-ablation
monitoring for arrhythmia recurrence is performed according to a standard clinical
follow-up schedule at 3, 6, and 12-months. ECG's are performed at each follow-up visit
along with placement of an ambulatory ECG-monitor. At 6-months post-ablation, cardiac
imaging with a repeat cardiac MRI or CT is performed.
Enrollment Count
2,478 participants
Eligibility Criteria
Inclusion criteria:
1. Age >18 years
2. Able to give written, informed consent
3. Scheduled for an ablation procedure to treat atrial fibrillation
Exclusion criteria:
1. None
Filters
Atrial Fibrillation
ACTIVE_NOT_RECRUITING
ADULT
OLDER_ADULT