Official Title
Genomic Investigation of Unusual Responders
Brief Title
Genomic Investigation of Unusual Responders
Protocol ID
NCT03740503
Lead Sponsor
University Health Network, Toronto
Brief Summary
Studies have shown that tumors from the same patient may respond very differently to the
same therapeutic agents. This study aims to investigate the genetic basis of tumors that
respond abnormally well or poorly to therapeutic agents in an effort to understand the
fundamental genetic basis of this response. The present protocol seeks to retrospectively
perform Exome, next-generation (DNA) sequencing and/or other molecular techniques on
tumor samples to identify the genetic basis of a patient's exceptional response to
chemotherapy.
Study Period
Enrollment Count
100 participants
Eligibility Criteria
Inclusion Criteria:
1. The patient must have either an exceptionally good or poor response to treatment, as
indicated by their treating physician.
1. The exact definition of this is adaptable to the disease but a suggested
guideline is a Complete Response, Partial Response or progression free interval
of at least 6 months
2. Exceptionally poor response includes patients who were expected to respond
favourably to a treatment but instead responded poorly (e.g dramatic tumor
growth or death)
2. The patient must have sufficient archival tumor available for sequencing.
3. Deceased patients will also be considered for analysis (up to 30 patients per year)
if they meet at least one of the following requirements:
a)) Patients who have archival tissue stored within the UHN Laboratory Medicine
Program who have had a consent waiver granted by the REB to access the tissue.
b) Patients who have archival tissue banked for further research within the UHN
Biospecimen Sciences Program
Exclusion Criteria:
- None
Filters
Cancer
Breast Cancer
Non-small Cell Lung Cancer
Colorectal Cancer
Genitourinary Cancer
Gynecological Cancer
Upper Aerodigestive Tract Cancer
Pancreatobiliary Gastrointestinal Cancer
Melanoma (Skin)
Rare Cancer
Carcinoma of Unknown Primary
RECRUITING
ADULT
OLDER_ADULT