Official Title
Storing Blood for Analysis of DNA and Protein of Patients With Cancer in MAASTRO Clinic
Brief Title
Biobank Carcinoma: Storing Blood and Protein of Patients With Cancer
Protocol ID
NCT01084785
Lead Sponsor
Maastricht Radiation Oncology
Brief Summary
The purpose of this study is to determine, by means of DNA and protein analysis, the
relationship between DNA and protein profiles and a number of endpoints, which are
important for the patient such as overall survival and side effects.
Detailed Description
It has already been known for a long time that cancer is a genetic disorder and that the
development of the illness is a very complex interaction between genetic and surrounding
factors. Also the response on therapy and the development and seriousness of side effects
is stipulated by this complicated collaboration of genetic and surrounding factors.
Moreover it is not only the DNA that plays an important role but also the systems of
control at protein level. At this moment a lot of questions remain to be answered because
up till now the studies were of rather restricted statistic strength with frequently
inconsistent dates and moreover retrospective. Major retrospective studies are necessary
to distinguish the relationship between DNA/protein patterns and clinical relevant
endpoints like prognosis and toxicity in which an as broad as possible patient group is
being monitored. For this reason we want to take blood samples in MAASTRO clinic of all
patients with lung cancer and to store it encrypted so that we can perform DNA and
protein analyses in future and to correlate the results with survival and toxicity of the
treatment.
Study Period
-
Enrollment Count
10,000 participants
Eligibility Criteria
Inclusion Criteria:
- cancer
Exclusion Criteria:
- not able to comply with follow-up
Filters
Cancer
RECRUITING
ADULT
OLDER_ADULT