Official Title
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
Brief Title
Genetic and Environmental Risk Factors for Hemorrhagic Stroke-GERFHS III
Protocol ID
NCT00930280
Lead Sponsor
University of Cincinnati
Brief Summary
The purpose of this study is to find risk factors for hemorrhagic stroke, specifically
intracerebral hemorrhage (ICH). ICH, a type of bleeding into brain tissue, is a type of
stroke that can result in death or disability in a large number of people. Our study
hopes to identify a specific genetic risk factor that will help identify at risk
individuals and target treatment strategies.
Detailed Description
Our case-control study will enroll subjects with a spontaneous ICH in the Greater
Cincinnati region. For each subject enrolled we will also enroll a healthy control
subject(matched by age , race and gender). Both the cases and control will undergo the
same interview and have blood drawn for genetic analysis. The cases will have a chart
abstraction done on their event medical record and be contacted for 3 and 6 month follow
up(short interview). The genetic sample will be genotyped using the Affymetrix 6.0 gene
chip looking for SNPs of interest and to identify genetic variants associated with ICH.
The most promising SNPs identified through this process will be replicated in the
external cohort from Massachusetts General Hospital.
Enrollment Count
1,260 participants
Eligibility Criteria
Inclusion Criteria:
- Age 18 years or older
- Resident (6 months or longer) within 100 miles of University of Cincinnati.
- Fulfillment of the criteria for spontaneous ICH
- No evidence of trauma, brain tumor/metastases, hemorrhagic transformation of
ischemic stroke or infectious processes as a cause of the hemorrhage.
- Ability of the patient or legal representative to provide consent for an interview,
blood pressure determinations and DNA sampling.
Exclusion Criteria:
- N/A
Filters
Stroke
ACTIVE_NOT_RECRUITING
ADULT
OLDER_ADULT