Official Title
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)
Brief Title
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)
Protocol ID
NCT01088217
Lead Sponsor
National Jewish Health
Brief Summary
The purpose of this study is to investigate inherited genetic factors that play a role in
the development of familial pulmonary fibrosis and to identify a group of genes that
predispose individuals to develop pulmonary fibrosis. Finding the genes that cause
pulmonary fibrosis is the first step at developing better methods for early diagnosis and
improved treatment for pulmonary fibrosis. The overall hypothesis is that inherited
genetic factors predispose individuals to develop pulmonary fibrosis.
Detailed Description
Familial Pulmonary Fibrosis (FPF) is a sub-category of the idiopathic interstitial
pneumonias (IIPs). IIPs are progressive lung conditions, with limited treatment options
and unknown etiology. Though the IIPs have been associated with both genetic risk factors
and environmental exposures, the molecular mechanism underlying disease progression
remain poorly understood. This investigation seeks to identify a group of genetic loci
that play a role in the development of familial interstitial pneumonia (FIP) or FPF,
where 2 or more cases of IIP are seen within a family.
Enrollment Count
8,000 participants
Eligibility Criteria
Inclusion Criteria:
- Two or more family members with a clinical diagnosis of Idiopathic Pulmonary
Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)
- Additional family members may be eligible to participate if two family members are
suspected of or diagnosed as having Idiopathic Pulmonary Fibrosis (IPF) or
Idiopathic Interstitial Pneumonia (IIP)
Exclusion Criteria:
- Individuals whose pulmonary fibrosis is due to a known cause rather than idiopathic
- Individuals whose pulmonary fibrosis is due to a broader genetic syndrome
Filters
Idiopathic Pulmonary Fibrosis
Familial Pulmonary Fibrosis
Idiopathic Interstitial Pneumonia
Familial Interstitial Pneumonia
UNKNOWN
CHILD
ADULT
OLDER_ADULT