Official Title
Establishment of Non-alcoholic Fatty Liver Disease Cohort and Development of Markers to Predict Histologic Progression of Liver Fibrosis
Brief Title
Establishment of NAFLD Cohort and Development of Fibrosis Markers
Protocol ID
NCT02206841
Lead Sponsor
Seoul National University Boramae Hospital
Brief Summary
This study is designed for establishment of non-alcoholic fatty liver disease patients
cohort to development of markers to predict histologic progression of liver fibrosis.
Detailed Description
- Acoustic radiation force impulse elastography and transient elastography
- Liver tissue (frozen tissue, paraffin block)
- Whole blood, Serum
- Fat amount ratio CT (Visceral adipose tissue, Subcutaneous adipose tissue amount)
- Body composition analyzer (InBody scale):Total fat/muscle mass and appendicular
skeletal muscle mass
- Pulmonary function test with post-bronchodilator response and DLCo
- EKG, EchoCG, Heart CT (Coronary calcium score), and Pusle wave velocity (AI index,
arterial stiffness)
- Brain MRI or CT
- Upper esophagogastroscopy and colonoscopy
- Berlin score questionnaire and Polysomnography
Study Period
-
Enrollment Count
1,000 participants
Eligibility Criteria
Inclusion Criteria:
- Patients with histologically confirmed fatty liver disease
- Patients with radiologically confirmed fatty liver disease
Exclusion Criteria:
- History of significant alcohol consumption
- Viral hepatitis
- Autoimmune hepatitis
- Metabolic diseases (e.g. hemochromatosis, M. Wilson, alpha 1-antitrypsin deficiency)
- Hepatotoxic medication (e.g. amiodarone)
Filters
Fibrosis of Liver
RECRUITING
ADULT
OLDER_ADULT