Official Title
The Chinese Early-onset Hypertension Study (CHESS)
Brief Title
The Chinese Early-onset Hypertension Study (CHESS)
Protocol ID
NCT02819674
Lead Sponsor
China National Center for Cardiovascular Diseases
Brief Summary
Hypertension (HTN) is the most important cardiovascular risk factor which is responsible
for 50% of cardiovascular morbidity and mortality, and also a substantial public health
problem affecting approximately 1/4 of the adult population in industrialized societies
and over 1 billion people worldwide. Chronically elevated blood pressure without well
control puts people at increased risk of target organ damages, including stroke,
myocardial infarction, congestive heart failure, end-stage renal disease, blindness, and
death. Especially, these damages are dramatically more severe in the early-onset
hypertensive population.
Detailed Description
In this study, the hypertensive individuals are consecutively recruited from multiple
centers, with an early onset age (less than 40 when diagnosed). A complete clinical
history (information on history of hypertension, demographic characteristics, personal
and family medical history) are collected by a trained staff using a standardized
questionnaire on the first day of baseline observation, and physical examination are also
collected in a standard procedure. Blood samples are collected after 12-hour overnight
fast and biological variables are determined. Genomic DNA is isolated from leukocytes
according to a standard procedure. The individuals will receive follow-up in an ordinal
system. The investigators will focus on the clinical and genetic features,
genotype-phenotype correlations and influencing factors of prognosis in Chinese
early-onset hypertension patients.
Enrollment Count
5,000 participants
Eligibility Criteria
Inclusion Criteria:
- In accordance with the diagnosis of hypertension (BP≥140/90mmHg), and less than 40
years when diagnosed
Exclusion Criteria:
-
Filters
Hypertension
UNKNOWN
CHILD
ADULT
OLDER_ADULT