Official Title
Translational-Omics in Aortic Stenosis (TOmAS) Biobank
Brief Title
Translational-Omics in Aortic Stenosis (TOmAS) Biobank
Protocol ID
NCT05930899
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Brief Summary
The objective of the TOmAS Biobank is the conservation of biological material (plasma,
saliva, and tissue explanted during surgery), genetic material (DNA, RNA, etc.), and
clinical data ("material/data") collected from patients with cardiovascular diseases
(CVD) as well as from control participants, in order to allow future studies evaluating
novel proteomic, transcriptomic and epigenomic markers (as well as other emerging -omic
technologies) for CVD (i.e. aortic stenosis, cardiomyopathy, myorcardial infarction,
etc). The study of physiological and genetic factors will allow for the discovery of new
genomic and other -omic (including proteomic, transcriptomic and epigenomic) biomarkers
associated with CVD which will lead to an improved understanding of the underlying
biology of CVD and may provide future insights into the prevention and treatment of this
type of disease.
Detailed Description
Inherited from parents, DNA is organized into genes and is unique to each individual.
Genes contain the information that dictates how cells function and hence, can also
influence the risk of developing diseases. Due to the uniqueness and variability between
each individual, genes can confer different risks of developing diseases when comparing
one person to another person (or a group of people). When a biological product can be
measured to predict whether someone is at a higher risk for a certain disease, it is
called a "biomarker". Biomarkers include, but are not limited to genetic material (such
as DNA) and certain proteins found in the heart and the blood. By studying genes and
proteins isolated from biological samples (blood, saliva and heart tissue), investigators
of this Biobank hope to characterize known biomarkers, identify novel biomarkers and
ultimately, improve the diagnosis and treatment of heart diseases.
The purpose of this research is to: (1) perform a genetic study of cardiovascular
diseases, such as aortic valve diseases and (2) create a biobank (that will include blood
samples, genetic material, and tissue explanted at surgery) to be used for analysis in
the future.
Study Period
-
Enrollment Count
10,000 participants
Eligibility Criteria
Inclusion Criteria:
- CVD diagnosis including, but not limited to: Aortic Stenosis, Coronary Heart
Disease, Heart Failure, Atrial Fibrilation, Dilated Cardiomyopathy, Myocardial
Infarction, and Spontaneous Coronary Artery Dissection.
- Undergoing cardiac surgery for non-aortic valve pathology
Exclusion Criteria:
- Individuals with Congenital heart disease will be excluded
Filters
Cardiovascular Diseases
Aortic Valve Stenosis
RECRUITING
ADULT
OLDER_ADULT