Official Title
Cohort of Twin Pregnancy and the Offspring
Brief Title
Cohort of Twin Pregnancy and the Offspring
Protocol ID
NCT05727085
Lead Sponsor
Fudan University
Brief Summary
Twin pregnancy increases the risk of maternal and fetal complications, which include
gestational hypertension, premature labor, twin-to-twin transfusion syndrome,
intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively
understanding the molecular mechanisms of the disease and identification of markers
contribute to development of novel therapeutic approaches. In addition, the twin
pregnancy, especially the monochorionic, is an essential model of "experiments of
nature". This model can be applied to distinguish the epigenetic differences of twins in
utero and after birth in the same genomic context. The aim of the study is to constitute
a prospective cohort of twin pregnancies and the offspring.
Detailed Description
Data are collected regarding the pregnancy data of the mother, and mental, physical and
sociodemographic information of the offspring. The periods span from diagnosis of twins
to 3 years old of the offspring. Biological samples would be collected including maternal
blood, placental tissues, cord blood, urine, and stool from the pregnant women or the
offspring at the specific time.
The total estimated duration of the study is 6 years, of which the first 2.5 years will
correspond to the recruitment period of the participants.
Study Period
-
Enrollment Count
1,000 participants
Eligibility Criteria
Inclusion Criteria:
1. Maternal age >18 years old.
2. Twin pregnancy.
Exclusion Criteria:
1. Fetal chromosomal or congenital abnormalities.
2. Stillbirth.
Filters
Twin Pregnancy
RECRUITING
ADULT
OLDER_ADULT