NCT06008392 - INTERogating Cancer for Etiology, Prevention and Therapy Navigation

Inclusion Criteria: GROUP A: Germline and Somatic Testing - Has Mayo Clinic medical record number - Confirmed cancer diagnosis - Germline and/or somatic tumor/blood testing has been ordered by the clinical provider (or clinical delegate) - Participant aware of cancer diagnosis - Able to provide informed consent - ≥ 18 years old - Ability to provide blood, saliva, bone marrow aspirate or hair follicle sample - Ability to provide archived tissue, if somatic testing has not already been completed - Note: if tissue unavailable participant may still enroll onto the study for the germline collection, or vice versa, if germline has already been completed may still enroll for somatic tissue/blood testing. GROUP B: Germline testing only: - Has Mayo Clinic medical record number - Confirmed cancer diagnosis - Germline testing has been ordered by the clinical provider (or clinical delegate) - Participant aware of cancer diagnosis - Able to provide informed consent - ≥ 18 years old - Ability to provide blood, saliva, or hair follicle sample GROUP C: Somatic tumor testing only: - Has Mayo Clinic medical record number, - Confirmed cancer diagnosis, - Somatic tumor/blood testing has been ordered by the clinical provider (or clinical delegate) - Participant aware of cancer diagnosis, - Able to provide informed consent, - ≥ 18 years old - Ability to provide archived tissue or blood for somatic tumor genomic profiling, if not already completed. Group D: Clinical standard of care germline testing via genetic counselor: - Has Mayo Clinic medical record number, - Standard of care clinical visit with genetic counselor - Confirmed cancer diagnosis, - Germline testing has been ordered by the clinical provider (or clinical delegate) - Participant aware of cancer diagnosis, - Able to provide informed consent, - ≥ 18 years old - Ability to provide blood, saliva, or hair follicle sample Group E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810: - Enrolled in any of the following studies: IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810 - Completed Riskguard, OncoExtra, Caris Assure, or Caris MI Profile or any combination of these tests. - Has Mayo Clinic medical record number, - Confirmed cancer diagnosis, - Participant aware of cancer diagnosis - Able to provide informed consent, - ≥ 18 years old Exclusion Criteria: Note: Women who are pregnant or planning to become pregnant can take part in this study. GROUP A: Germline and Somatic testing - Individuals who have situations that would limit compliance with the study requirements - Institutionalized (i.e. Federal Medical Prison) GROUP B: Germline testing only - Individuals who have situations that would limit compliance with the study requirements - Institutionalized (i.e. Federal Medical Prison) - Prior germline genetic testing with a 100+ multi-gene panel within the last 1 year of enrollment Group C: Somatic tumor testing only: - Individuals who have situations that would limit compliance with the study requirements, - Institutionalized (i.e. Federal Medical Prison), Group D: Clinical standard of care germline testing via genetic counselor: - Individuals who have situations that would limit compliance with the study requirements, - Institutionalized (i.e. Federal Medical Prison) Group E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810: - Individuals who have situations that would limit compliance with the study requirements, - Institutionalized (i.e. Federal Medical Prison)