Official Title
Identification of Genetic Causes of Calcific Aortic Valve Disease
Brief Title
Identification of Genetic Causes of Calcific Aortic Valve Disease
Protocol ID
NCT04149600
Lead Sponsor
Beth Israel Deaconess Medical Center
Brief Summary
This study aims to identify the molecular genetic causes of the variability in
development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and
their associated aortic dilation.
Study Period
-
Enrollment Count
1,000 participants
Eligibility Criteria
Inclusion Criteria:
- Patients with a plan to undergo elective aortic valve replacement and/or ascending
aortic surgery
Exclusion Criteria:
- Age < 20 years
- Unable/unwilling to consent
- History of aortic valve replacement or transcatheter aortic valve replacement (TAVR)
- History of endocarditis
- History of rheumatic fever
- History of chest radiotherapy
- History of organ transplant
Filters
Calcific Aortic Stenosis
Calcific Aortic Stenosis - Bicuspid Valve
Aortic Valve Disease
Aortic Valve Calcification
Aortic Diseases
Aortic Aneurysm
Aortic Valve Cusp Abnormality
Aortic Valve Disease Mixed
Aortic Valve Insufficiency
ACTIVE_NOT_RECRUITING
ADULT
OLDER_ADULT