Official Title
Variants in Taste Genes on Caries Risk and Caries Activity Status
Brief Title
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries
Protocol ID
NCT04066101
Lead Sponsor
Recep Tayyip Erdogan University Training and Research Hospital
Brief Summary
The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene
polymorphism on caries risk in adults.
Detailed Description
To date, genes can be grouped into categories based on the factor influencing dental
caries. The major candidate gene categories to date include enamel formation genes,
immune response genes, genes related to saliva, and genes related to taste and dietary
habits.
CA6 exists in the human saliva and has a critical role of buffering, immune response and
taste.Toll-like receptors are expressed in the tongue gustatory papillae where they may
initiate immune responses to pathogens.Genetic variations in the TAS1R1 and TAS1R3 for
umami cause perception of these tastes differently.
Study Period
-
Enrollment Count
200 participants
Eligibility Criteria
Inclusion Criteria:
- adult be between 25 and 44 years old
- subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) ≥ 5, or, DMFT ≥14
- same oral health, diet and socioeconomic status
Exclusion Criteria:
- systemic or genetic disorders
- orthodontic appliances
- pregnant women
Filters
High Caries Risk
Low Caries Risk
COMPLETED
ADULT