Official Title
Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes
Brief Title
Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes
Protocol ID
NCT03578835
Lead Sponsor
University Hospital Tuebingen
Brief Summary
Continual surveillance of both community-acquired and nosocomial bloodstream infections
for specific target organisms. Analysis of comorbidities, complications, bacterial
resistance patterns, bacterial genomics (e. g. via WGS and MLST typing) for the
determinants of clinical outcomes. The clinical outcomes are investigated both in the
short-term (up until discharge) and the long-term (six months after index blood culture
by standardized questionnaire). A predictive point-of-care score is to be developed based
on these data to define high-risk patient populations requiring more intensive diagnostic
and/or treatment regimens.
Study Period
-
Enrollment Count
6,000 participants
Eligibility Criteria
Inclusion Criteria:
- At least 18 years old
- Informed consent given either by patient or guardian
- Inpatient
- At least one blood culture positive for one of the following bacteria:
Staphylococcus aureus, Enterococcus spp., Escherichia coli, Enterobacter spp.,
Klebsiella spp., Acinetobacter baumannii, Pseudomonas aeruginosa
Exclusion Criteria:
- Less than 18 years old
- Not capable of giving informed consent nor informed consent given by guardian
- Outpatient
- No blood cultures positive for any of the target organisms
Filters
Bloodstream Infection
Septic Shock
UNKNOWN
ADULT
OLDER_ADULT