Precision Health Clinical Trials

The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Conditions:   Gastrointestinal Cancer;   Head and Neck Cancer;   Dihydropyrimidine Dehydrogenase Deficiency;   UGT1A1 Gene Mutation;   Breast Cancer
Intervention:   Other: Availability of clinical decision support based on pharmacogenomic results.
Sponsor:   University of Chicago
Recruiting

For more information, visit the Study URL.

Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)

Conditions:   Lung Cancer, Non-small Cell;   EGFR Gene Mutation;   EGFR-TKI Resistant Mutation;   Primary Resistance;   Circulating Tumor DNA
Interventions:   Other: Genomic profiles detection;   Other: circulating tumor DNA detection
Sponsors:   Second Xiangya Hospital of Central South University;   Xiangya Hospital of Central South University;   Shanghai Chest Hospital;   West China Hospital;   Hunan Cancer Hospital;   The Third Xiangya Hospital of Central South University;   The First Affiliated Hospital of Xiamen University;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   China-Japan Friendship Hospital;   Fudan University;   First Affiliated Hospital of Kunming Medical University;   Loudi Central Hospital;   ZhuZhou Central Hospital;   Xiangtan Central Hospital;   First People's Hospital of Chenzhou;   Yueyang Central Hospital;   Yongzhou Central Hospital;   The First Affiliated Hospital of University of South China;   Hunan Provincial People's Hospital;   Shaoyang Central Hospital;   Yiyang Central Hospital;   Changsha Central Hospital;   The first people's hospital of Guiyang;   Wuhan Union Hospital, China;   Renmin Hospital of Wuhan University;   The First People's Hospital of Changde;   Zhuzhou Second Hospital;   First Hospital of Changsha;   Hengyang Central Hospital;   Huaihua first people's Hospital;   The First People's Hospital of Xiangtan;   University of South China Affiliated Nanhua Hospital;   Xiangxi Autonomous Prefecture People's Hospital;   People's Hospital of Zhangjiajie;   Second People's Hospital Of Huaihua;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   The Third Hospital of Changsha;   Xiangya Changde Hospital;   Changsha County first People's Hospital;   Hunan Provincial Straight Hospital of Traditional Chinese Medicine;   Liuyang Hospital of traditional Chinese Medicine;   Second People's Hospital of Hunan;   First Affiliated Hospital of Guangxi Medical University;   Guiyang Public Health Treatment Center;   The Affiliated Bethune Hospital of Shanxi Medical University;   The First Affiliated Hospital of Hunan University of Chinese Medicine;   Tongji Hospital;   The First Affiliated Hospital of Nanchang University
Recruiting

For more information, visit the Study URL.

Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C

Condition:   Niemann-Pick Disease, Type C
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

For more information, visit the Study URL.

Molecular Characterization of Blastocystis Isolates From Human by Restriction Fragment Length Polymorphism (RFLP) Analysis

Condition:   Blastocystis Infections
Intervention:   Diagnostic Test: RFLP analysis of SSU rRNA
Sponsor:   Sohag University
Not yet recruiting

For more information, visit the Study URL.

Molecular Epidemiology of Pediatric Germ Cell Tumors

Conditions:   Germ Cell Tumor;   Germinoma;   Teratoma;   Embryonal Carcinoma;   Yolk Sac Tumor;   Choriocarcinoma;   Mixed Germ Cell Tumor;   Late Effects;   Pediatric Germ Cell Tumor
Interventions:   Other: Questionnaire Administration;   Other: Tumor Specimen Collection;   Other: Germline DNA Samples;   Procedure: Blood Sample Collection
Sponsor:   Children's Oncology Group
Recruiting

For more information, visit the Study URL.

A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)

Condition:   Colorectal Cancer
Intervention:  
Sponsor:   Memorial Sloan Kettering Cancer Center
Recruiting

For more information, visit the Study URL.

The Energy Cost of Living in the Developing World

Condition:   Food Requirements
Intervention:   Other: No intervention
Sponsors:   Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences;   Université Cheikh Anta Diop de Dakar;   Moi University;   Tehran University of Medical Sciences;   Imperial College London Diabetes Centre
Not yet recruiting

For more information, visit the Study URL.

Precision Medicine for Liver Tumours With Quantitative Magnetic Resonance Imaging and Whole Genome Sequencing

Conditions:   Liver Cancer;   Liver Metastasis Colon Cancer
Intervention:   Genetic: utility of whole genome sequencing (WGS) to aid clinical decision making in patients referred for liver resection
Sponsor:   Perspectum
Recruiting

For more information, visit the Study URL.

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Azacitidine;   Procedure: Biospecimen Collection;   Procedure: Bone Marrow Aspirate;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Venetoclax
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

For more information, visit the Study URL.

The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan

Condition:   Oropharyngeal Squamous Cell Carcinoma
Intervention:  
Sponsors:   National Health Research Institutes, Taiwan;   National Taiwan University Hospital;   Taipei Veterans General Hospital, Taiwan;   China Medical University Hospital;   Taichung Veterans General Hospital;   National Cheng-Kung University Hospital;   Kaohsiung Veterans General Hospital.
Recruiting

For more information, visit the Study URL.

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